Research Article
Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study
Table 4
Blood paced cell volume (PCV), serum N-terminal pro-brain natriuretic peptide (NT-pro BNP), plasma atrial natriuretic peptide (ANP), blood urea nitrogen, creatinine, total protein, sodium, potassium, and chloride after eplerenone (EP) administration in dogs.
| | Variables | Group | Time after EP administration (weeks) | | 0 | 1 | 2 | 4 |
| | PCV (%) | EP 2.5 | 46.1 ± 1.3 | 43.8 ± 1.5 | 45.3 ± 1.9 | 45.0 ± 1.5 | | EP 5 | 45.6 ± 2.7 | 44.2 ± 2.0 | 45.2 ± 3.0 | 45.3 ± 3.1 | | EP 10 | 44.4 ± 2.6 | 45.7 ± 2.6 | 44.8 ± 2.3 | 43.9 ± 2.3 |
| | NT-pro BNP (pmoL/L) | EP 2.5 | 180 ± 53 | 212 ± 44 | 277 ± 72 | 186 ± 75 | | EP 5 | 404 ± 105 | 228 ± 68 | 327 ± 87 | 404 ± 81 | | EP 10 | 209 ± 72 | 266 ± 42 | 277 ± 53 | 224 ± 48 |
| | ANP (pg/mL) | EP 2.5 | 41.3 ± 6.1 | 31.1 ± 5.9 | 39.0 ± 8.2 | 29.5 ± 6.3 | | EP 5 | 44.6 ± 12.5 | 42.8 ± 12.8 | 33.8 ± 6.8 | 29.5 ± 4.8 | | EP 10 | 40.1 ± 12.7 | 24.4 ± 3.4 | 27.6 ± 6.2 | 25.6 ± 2.7 |
| | Blood urea nitrogen (mg/dL) | EP 2.5 | 16.3 ± 1.2 | 17.3 ± 0.7 | 14.0 ± 1.0 | 19.4 ± 1.4 | | EP 5 | 14.7 ± 0.8 | 16.2 ± 1.4 | 17.4 ± 2.3 | 16.4 ± 1.9 | | EP 10 | 15.5 ± 1.3 | 14.7 ± 0.8 | 14.8 ± 1.2 | 12.9 ± 0.8 |
| | Creatinine (mg/dL) | EP 2.5 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | | EP 5 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | | EP 10 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 |
| | Total protein (g/dL) | EP 2.5 | 6.0 ± 0.1 | 6.1 ± 0.1 | 6.1 ± 0.1 | 6.2 ± 0.1 | | EP 5 | 6.0 ± 0.1 | 6.1 ± 0.2 | 6.1 ± 0.1 | 6.2 ± 0.1 | | EP 10 | 6.1 ± 0.1 | 6.2 ± 0.1 | 6.3 ± 0.2 | 6.3 ± 0.1 |
| | Sodium (mmoL/L) | EP 2.5 | 145 ± 0.2 | 145 ± 0.4 | 146 ± 0.6 | 146 ± 0.8 | | EP 5 | 146 ± 0.2 | 144 ± 0.8 | 146 ± 0.5 | 144 ± 1.4 | | EP 10 | 144 ± 0.7 | 145 ± 0.7 | 145 ± 1.1 | 144 ± 0.4 |
| | Potassium (mmoL/L) | EP 2.5 | 4.4 ± 0.2 | 4.3 ± 0.2 | 4.4 ± 0.1 | 4.2 ± 0.1 | | EP 5 | 4.2 ± 0.2 | 4.1 ± 0.1 | 4.0 ± 0.2 | 4.0 ± 0.2 | | EP 10 | 4.2 ± 0.1 | 4.2 ± 0.1 | 4.0 ± 0.1 | 4.2 ± 0.1 |
| | Chloride (mmoL/L) | EP 2.5 | 115 ± 1.4 | 116 ± 1.1 | 116 ± 0.8 | 116 ± 1.6 | | EP 5 | 118 ± 0.7 | 116 ± 0.7 | 116 ± 0.9 | 117 ± 0.9 | | EP 10 | 116 ± 1.0 | 114 ± 1.6 | 116 ± 1.7 | 115 ± 1.3 |
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Each value represents the mean ± standard error ( ). EP 2.5, 5, and 10: eplerenone 2.5, 5, and 10 mg/kg, respectively. |
