Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads (Rhinella marina)

Table 1

Pharmacokinetic parameters from a noncompartmental model using plasma data from toads (n = 21) given a single transdermal dose of 3.3 mg/kg flunixin meglumine. λ_z = rate constant associated with the terminal elimination phase; t_1/2λz = half-life of the terminal elimination phase; AUC_0⟶∞ = total area under the curve; %AUC_extrap = area under the curve extrapolated as a percentage of the total; CL/F = total body clearance; Vd = volume of distribution; t_max = time to maximum concentration; C_max = maximum plasma concentration.

Parameter	Units	Mean
λz	h^−1	0.25
t1/2λz	h	2.79
AUC0⟶	h^∗µg/ml	29.37
%AUCextrap	%	0.28
CL/F	ml/h/kg	112.36
Vd/F	ml/kg	452.29
tmax	h	1
Cmax	µg/ml	6.31