Review Article
Rotavirus in Calves and Its Zoonotic Importance
Table 1
Rotavirus proteins, genome segments, and structural localization.
| | Protein | dsRNA segment no | Location in virus capsid | Function | Numbers of molecules/virion |
| | VP1 | 1 | Core | dsRNA synthesis (RNA-dependent RNA polymerase) | 12 | | VP2 | 2 | Core | Inner shell protein | 120 | | VP3 | 3 | Core | Capping enzyme | 12 | | VP4 (cleaved to VP5 and VP8) | 4 | Outer capsid | Viral attachment, P-type neutralization antigen | 120 | | VP6 | 6 | Inner capsid | Middle shell protein | 780 | | VP7 | 9 | Outer capsid | G type neutralization antigen | 780 | | NSP1 | 5 | | INF antagonist | — | | NSP2 | 8 | | Viroplasm formation | — | | NSP3 | 7 | | Enhance viral mRNA synthesis, associated with systemic spread | — | | NSP4 | 10 | | Outer capsid assembly, regulate calcium homeostasis, enterotoxin | — | | NSP5 | 11 | | Viroplasm formation | — | | NSP6 | 11 | | Viroplasm formation | — |
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