Review Article

Folic Acid: Sources, Chemistry, Absorption, Metabolism, Beneficial Effects on Poultry Performance and Health

Table 2

Effect of folic acid in the animal.

AnimalDose rateMajor findingsReferences

Laying hensBasal diet added FA 4 mg/kgIncreased egg weight and egg mass, decreased serum glucose levels, and serum uric acidJing et al. [50]

Laying hensBasal diet added FA 10 or 100 mg/kgIncrease egg and plasma folate concentrations and also decrease the transport of FA in the duodenumTactacan et al. [54]

Laying hensBasal diet added 10 mg/kg of FAAffects the activity of plasma homocysteine, methionine synthase, and hepatic serine hydroxymethyltransferase. And egg folate concentrationsTactacan et al. [59]

Laying hensFA added 4 mg/kgEnriches the FA content of eggsDickson et al. [45]

Laying hensBasal diet added with chromium yeast (150 mg ton−1) + FA (10 mg ton−1)Increase in the feed conversion, decrease in feed consumption, and egg yolk cholesterolEseceli et al. [60]

Laying hensBasal diet added FA 50 mg/kgIncrease the body weight of the newly hatched chicksTerčič and pestotnik [41]

Laying hensBasal diet added FA 24 mg/kgIt affects the cecum by reducing pathogenic bacteriaBai et al. [30]

Laying hensBasal diet added FA 5, 10, and 15 mg/kgIt affects egg yolks by increasing 5-MTHF content and egg productionBagheri et al. [27]

Laying hensBasal diet added 4 mg/kg of crystalline FAAffect the accumulation of folate in eggsHebert et al. [45]

Laying hensBasal diet added 2 and 4 ppm FAIncreased egg productionKrishnan [43]

Laying hensBasal diet added BET (1,0 g/kg) and FA (1,0 mg/kg)Increases in haugh units, egg weight, shell thickness, sperm motility, and decreased dead spermatozoaEzzat et al. [49]

Hepatocytes from new-hatched male chicksThe concentration of FA in the culture medium is 15 mg/LInhibits de novo fatty acid synthesis and promotes hydrolysis and exportation of triglyceride in primary chicken hepatocytesLiu et al. [9]

BroilersBasal diet added 200 mg L-ascorbic acid plus 1.5 mg FA/kgCan improve the antioxidant status, growth, and health status of broilers under heat stressGouda et al. [25]

Broilers2.0 mg/kg folate added to feedLess significantly affect product performance and slaughter performanceZhang et al. [12]

BroilersFA (13.0 mg/kg), meth (0.25%), and B12 (0.15 mg/kg) were added to feedPositive effect on FCR, egg weight, hatchability, and weight of DOCEl-Husseiny et al. [48]

BroilersFA was added to the feed at 5 mg/kg and 10 mg/kgReduce fat accumulation by regulating gene expressionZhang et al. [7]

BroilersThe basal diet was supplemented with 0.25, 1.25, 2.50, and 5.00 mg/kg−1 folateCould regulate glucose and lipid metabolism in broilersWu et al. [11]

Laying quailsFA as much as 4 and 8 mg/kg added to the feedSignificantly increase FA content and egg yolk colorSadegheymojarad et al. [21]

TurkeyBasal diet added FA 1–2 mg/kgIncrease the vitamin content in eggs, increase the weight of chicks, and their growthBarroeta et al. [43]