Review Article

Folic Acid: Sources, Chemistry, Absorption, Metabolism, Beneficial Effects on Poultry Performance and Health

Table 3

Effect of folic acid on poultry health.

AnimalDose rateMajor findingsReferences

BroilerBasal diet added L-ascorbic acid (AA) 200 mg/kg and FA 1.5 mg/kgIncrease thyroid hormone, hemoglobin, insulin growth factor, albumin, globulin, total protein, antioxidant activity, and antibodies against virusesGouda et al. [25]

Laying hensBasal diet added FA 24 mg/kgReducing pathogens in the cecumBai et al. [30]

BroilerBasal diet added ten ppm FAIncreases bile acid concentration and heart weightFisayo et al. [61]

Laying hensBasal diet added FA 4 mg/kgLowers serum glucose and uric acid levelsJing et al. [50]

Laying hensBasal diet added FA 4 mg/kgEnhances biochemical constituents, IgG, and exhibits pleiotropic activityMunyaka et al. [55]

Broiler15 mg/L in the culture of primary chicken hepatocytesInhibits de novo fatty acid synthesis and can promote triglyceride hydrolysisLiu et al. [9]

BroilerPoultry supplemented with FA 800 mg/lCan reduce liver lipogenesis, suppress adipocyte proliferation and differentiationLiu et al. [10]

BroilerPoultry supplemented with FA 16 mg/LIncrease adipocyte proliferationYu et al. [8]

BroilerBasal diet added FA 0.25–5.00 mg/kgAffect lipid and glucose metabolism in chicken progenyWu et al. [11]

Broiler fertile eggs50–150 μg folic acid was injected into eggsUpregulates IGF2 expression and aids organ developmentLiu et al. [62]