Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice

Table 3

Differences in plasma level of SGOT and SGPT of P. berghei ANKA-infected mice treated with EECS compared with the control groups.

Groups	Parasitemia (%)		Suppression (%)	SGOT (U/L)	SGPT (U/L)
	D0	D4
Negative control	1.24 ± 0.69	14.42 ± 7.86	—	658.75 ± 99.52	167.75 ± 32.37
EECS 150 mg/kg	2.13 ± 1.19	8.77 ± 4.42	51.85	384.75 ± 73.98	75.75 ± 35.52
EECS 200 mg/kg	0.98 ± 0.64	9.42 ± 3.27	58.93	216.00 ± 48.80	42.00 ± 4.50
Chloroquine	2.30 ± 1.44	0.14 ± 0.28	100.00	175.50 ± 45.59	41.25 ± 5.60
Healthy control	—	—	—	162.50 ± 59.18	97.25 ± 44.70

Data are expressed as mean ± standard deviation (n = 4). No significant difference between the groups (; one-way ANOVA followed by Tukey’s multiple comparison test). D₀: day before the treatment; D₄: fourth day after treatment; SGOT: plasma glutamic oxaloacetic transaminase; SGPT: plasma glutamic pyruvic transaminase; EECS: 90% ethanolic leaf extract of Cassia spectabilis DC.