Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected with Plasmodium berghei

Table 4

Effect of allicin and its combination with ART on rectal temperature in PbANKA infection in mice.

Group	Dose (mg/kg)			Rectal temperature (°C)
	UN	Allicin	ART	D0	D4	% change
Single	10 ml/kg of 20% Tween-80	—	—	36.40 + 0.14	34.42 + 0.26	−5.44
	—	14	—	36.22 + 0.21	35.91 + 0.17	−0.86
	—	—	5	36.67 + 0.18	36.22 + 0.23	−1.23
Combination (1 : 1)	ED50	14	5	36.18 + 0.24	36.65 + 0.18	1.30^,##
	ED50 1/2	7	2.5	36.53 + 0.29	36.55 + 0.29	0.05^,##
	ED50 1/4	3.5	1.25	36.02 + 0.34	35.58 + 0.25	−1.22
	ED50 1/8	1.75	0.625	36.90 + 0.27	34.21 + 0.45	−7.29

and compared to UN. ^## compared to allicin and ART.