Research Article
Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected with Plasmodium berghei
Table 4
Effect of allicin and its combination with ART on rectal temperature in PbANKA infection in mice.
| Group | Dose (mg/kg) | Rectal temperature (°C) | UN | Allicin | ART | D0 | D4 | % change |
| Single | 10 ml/kg of 20% Tween-80 | — | — | 36.40 + 0.14 | 34.42 + 0.26 | −5.44 | — | 14 | — | 36.22 + 0.21 | 35.91 + 0.17 | −0.86 | — | — | 5 | 36.67 + 0.18 | 36.22 + 0.23 | −1.23 | Combination (1 : 1) | ED50 | 14 | 5 | 36.18 + 0.24 | 36.65 + 0.18 | 1.30,## | ED50 1/2 | 7 | 2.5 | 36.53 + 0.29 | 36.55 + 0.29 | 0.05,## | ED50 1/4 | 3.5 | 1.25 | 36.02 + 0.34 | 35.58 + 0.25 | −1.22 | ED50 1/8 | 1.75 | 0.625 | 36.90 + 0.27 | 34.21 + 0.45 | −7.29 |
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and compared to UN. ## compared to allicin and ART. |