Review Article

Lycopene in Feed as Antioxidant and Immuno-Modulator Improves Broiler Chicken’s Performance under Heat-Stress Conditions

Table 1

Antioxidant effects of lycopene in the broiler’s feed.

AnimalsSupplemental doseMajor findingsReferences

Broiler5% lycopene/kg in feedDecreasing triglycerides, decreasing MDA concentration, and increasing SOD, GPx, ALT, AST, ALP, and lipase concentrationHosseini-vashan, [8]
Broiler0 and 75 mg/kg lycopene in feedImprovement of oxidative stabilityEnglmaierová et al., [9]
Broiler0, 200, 400 mg/kg lycopene in feedControlling the antioxidant activity of the Nrf2 and NF-kB pathways, muscle keap1, muscle Nrf2, muscle lycopene levels, and the activities of GSH-Px and SODMost and yates, [10]
Broiler50–100 mg/kg lycopene in feedDecreased the concentration of MDASevcikova et al. [11]
Broiler200–400 mg/kgLowered of cholesterol and MDA and increased activity of HDLC, GPx, and SOD in bloodFathi et al., [12]
Broiler breeder rooster0.1–0.3 mMImprove the quality of rooster spermatozoa after thawing, increase the viability of the hatching eggsNajafi et al., [13]
Broiler exposed aflatoxin B1200 mg/kgEnhanced GSH, GPx, and SOD activities and decreased H2O2 dan ROS concentrationWan et al., [14]
Broiler exposed aflatoxin B1200 mg/kgImproved the redox stability by augmenting the antioxidant enzyme activity and their associated mRNA expression levelsSarker et al., [15]
Broiler10–30 mg/kgRaised performance, antioxidant enzyme activities in serum and liver and upregulates genes Keap1-Nrf2Wang et al., [16]
Broiler50–200 mg/kgDecreased MDA, triglyceride, cholesterol, ALP, ALT and increase catalase, GPx in blood serumMezbani et al., [17]
Broiler10–20 mg/kgLowered LDLC, triglyceride and prevents oxidation od LDLC in liver and serumLee et al., [18]
Arbor acres broiler100, 200, 400 mg/kgImproved growth performance, BW, decrease abdominal fat, plasma lipid level, and hepatic enzymatic activityWan et al., [16]
Arbor acres broiler (AFB1 challenge)100, 200, 400 mg/kgDecreased ALT, AST, CYP2A6 activities, and hepatic CYP1A1 and increased antioxidant statusWan et al., [14]
Arbor acres broiler (AFB1 challenge)100, 200, 400 mg/kgIncreased growth performance, digestive enzyme, and intestinal morphologySarker et al., [19]
Ross 308 broiler (heat-stress conditions)200, 400 mg/kgIncreased growth performance, serum antioxidant status, and muscle antioxidant statusSahin et al., [20]
Hubbard broiler500 mg/kgDecreased growth performance, slaughter performance,Puzzo et al., [21]

MDA: malondialdehyde; SOD: superoxide dismutase; GPx: glutathione peroxidase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GSH: reduced glutathione; GSSG: oxidized glutathione; T3: triiodothyronine; HDLC: high density lipoprotein cholesterol; LDLC: low-density lipoprotein cholesterol; NF-kB: nuclear factor kB; Nrf2: nuclear factor erythroid 2-related factor; keap1: Kelch-like-ECH-associated protein 1; H2O2: hydrogen peroxide; ROS: reactive oxygen species.