Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells

Figure 1

Alphavirus genome. The alphavirus genome is single-stranded, positive-sense RNA, encoding two open reading frames. The nonstructural proteins are translated from the genomic RNA while the structural proteins are translated from subgenomic 26S RNA (promoter as indicated). The two polyproteins are cleaved by viral cysteine, and host proteases to generate the individual protein products. *denotes leaky stop codon.