Turnover of Focal Adhesions and Cancer Cell Migration

Figure 4

Domain structures of FA disassembly factors. FAK: FERM (protein 4.1, ezrin, radixin, and moesin homology), PR (proline-rich motif), FAT (focal adhesion targeting), pY (phosphorylated tyrosine), Dynamin: PH (pleckstrin homology), GED (GTPase effector domain), PTP-PEST: PR (proline-rich motif), SHP-2: SH2 (src homology 2 domain), PTP-1B: PR (proline-rich motif), ERTD (endoplasmic reticulum-targeting domain), m-Calpain: I (possible autoinhibitory region), IIa and IIb (protease domain), III (putative phospholipid-binding sites), and IV (the region containing 4 EF-hand motifs), ZF21: FYVE (Fab1, YOTB, Vac1, and EEA1), PH-like (pleckstrin homology-like).