Phenotypic and Cytogenetic Characterization of Mesenchymal Stromal Cells in De Novo Myelodysplastic Syndromes

Figure 4

Cytogenetic findings of MDS derived MSCs. (a) Chromosomal abnormalities of MDS-MSCs. Distinct chromosomal abnormalities were found in three patients: 46,XX,der(3) in 14-020, 46,XY,del(6)(q23q26) in 14-072, and 38~43,XY,del(7)(p21p22) in 14-080. (b) FISH analysis of bone marrow (i) and MSCs (ii) of del(5q) patient (14-081). Bone marrow contained two clones; the normal cells showed two red and two green signals and the cells in the abnormal clone showed one red and one green signal. MSCs of this patient showed two red and two green signals indicating the absence of del(5)(q31.2q33).

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