Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland

Figure 3

Histological analysis of lacrimal tumors in Brca1^co/coMMTV-cre mice. (a) High-power view of an H&E-stained section of the 9 months of age case (Figure 2(c)) shows acinic cell carcinoma (asterisk), characterized by variable-sized cystic spaces lined by simple or stratified cuboidal epithelium with some papillary projections. Yellow lines separate the tumor (asterisks) and nonneoplastic lacrimal gland (N). The retrobulbar tumor is separated from the eyeball (E) by the skeletal muscle. (b) Higher-magnification view of the boxed area. Variable vacuolated, clear tumor cells mimicking adjacent nonneoplastic serous acinar cells of the lacrimal gland were found. (c) A poorly differentiated, predominantly solid component with a scant glandular pattern is noted in an H&E-stained section of the 17 months of age case (Figure 2(b)). Scale bars: 200 μm.

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