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Autoimmune Diseases
Volume 2012, Article ID 105205, 7 pages
http://dx.doi.org/10.1155/2012/105205
Review Article

Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet’s Disease

1Department of Immunology and Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki 216-8511, Japan
2Department of Medicine, Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan

Received 16 July 2012; Accepted 23 August 2012

Academic Editor: Kamal D. Moudgil

Copyright © 2012 Jun Shimizu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Behcet’s disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current findings on HSP reactive T cells and their contribution to the pathogenesis in patients with BD.