Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice
CRPtg, but not nCRPtg mice, are resistant to EAE. Wildtype, CRPtg, and nCRPtg mice were immunized with MOG peptide and symptoms of EAE were monitored over the course of 30 days. EAE onset was significantly delayed and its symptoms ameliorated in CRPtg, but not in nCRPtg (see Table 1).
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.