Case Report
Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
Table 2
Morphology, cytochemistry and immunocytochemistry.
| | | Case I | Case II | Case
III | Case IV | Case V |
| | Morphology | | | | | | |
| | Peripheral smear | *Red cells | | | | | | | Normocytic Normochromic
| Present
| Present
| Present
| Present
| Present with tear drop cells
| | *Blasts (%)
| 18%
| 40%
| 4%
| 5%
| 25%
| | *Blast morphology | | | | | | | (i) agranular blue cytoplasm with cytoplasmic blebbing
| Present
| Present
| Present
| Present (some blasts were granular)
| Present
| | (ii) Giant platelets
| Present
| Absent
| Absent
| Absent
| Present
| | (iii) Platelet budding
| Present
| Present
| Absent
| Absent
| Present
|
| | Bone marrow aspiration/biopsy | *Hypercellular marrow showing megakaryoblasts, micromegakaryocytes,
promegakaryocytes (full range of differentiation)
| Present with clustering mimicking metastasis
| Present
| Present
| Diluted BMA & Biopsy showed blasts with clustering and
increased reticulin fibres
| Present
| | *Blast (%) | 25% | 45% | 56% | 25% (biopsy) | 28% |
| | Cytochemistry | | | | | | |
| | PAS
| Positive
| Positive
| Negative
| Positive
| Positive
| | NSE
| Positive, fluoride resistant
| Positive, fluoride resistant
| Positive, fluoride resistant
| Positive, fluoride resistant
| Positive, fluoride resistant
| | MPO/SBB | Negative | Negative | Negative | Negative | Negative |
| | Immunocytochemistry | | | | | | |
| | Lymphoid markers (CD5, 7,19, 20)
| Negative
| Negative
| Negative
| Negative
| Negative
| | Myeloid markers (CD13,33)
| Negative
| Negative
| Negative
| Negative
| Equivocal
| | CD61 (Gp Illa) | Positive | Positive | Positive | Positive | ND |
|
|
