Case Report
Temozolomide-Induced Myelodysplasia
Table 1
Estimated CDT for selected potentially leukemogenic agents.
| Compound | Activity | CDT (mg/sq m) | Latency to MDS/AML (yrs) |
| Temozolamide | alkylating agent | 18–20,000 | 0.75–3 | Cyclophosphamide | alkylating agent | 8–10,000 | 2–10 | Alkeran | alkylating agent | 80 | 2–10 | Mechlorethamine | alkylating agent | 60 | 2–10 | Etoposide | topo II inhibitor | 2,000 | 1–4 | Mitoxantrone | topo II inhibitor | 60 | 0.50–5 | Benzene | unknown | 46,000 | 2–10 |
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