Predicting the Kinetic Properties Associated with Redox Imbalance after Oxidative Crisis in G6PD-Deficient Erythrocytes: A Simulation Study
Figure 4
Comparison of G6PD kinetic parameters and steady state value, recovery time, and amount of change in GSH/GSSG in individuals. (a) The relationship between and and the evaluation criteria in real patients (Table 1). Dark gray dots represent G6PD-deficient patients, and the light gray dots represents the control. (b) The relationship between and and the evaluation criterions in virtual G6PD patients created from randomly selected parameters (Table 2). Recovery time denotes the time required for the GSH/GSSG to return to its initial value after perturbation, and amount of change is calculated by (2) in the text. Note that a few patients exhibiting abnormal recovery time (>30 min, 0.4% the of original number of patients) have been eliminated from the plot. The data displayed here were obtained from a single simulation run, which was representative of 15 simulation runs.
