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Advances in Materials Science and Engineering
Volume 2017, Article ID 2784303, 7 pages
Research Article

Catalytic Synthesis and Antifungal Activity of New Polychlorinated Natural Terpenes

1Laboratory of Biomolecular and Medicinal Chemistry, URAC 16, Faculty of Sciences Semlalia, Marrakech, Morocco
2Laboratoire de Chimie et Modélisation Mathématique, Faculté Polydisciplinaire de Khouribga, Université Hassan 1er, BP 145, 25000 Khouribga, Morocco
3Equipe de Chimie de Coordination et Catalyse, Département de Chimie, Faculté des Sciences Semlalia, Université Cadi Ayyad, BP 2390, 40001 Marrakech, Morocco
4Laboratory of Phytopathology, Genetics and Integrated Control (LPGLI), National Institute of Agricultural Research (INRA), P.O. Box 533, Marrakesh, Morocco

Correspondence should be addressed to Larbi El Firdoussi; and Hassan Bihi Lazrek; moc.liamg@05kerzalbh

Received 2 May 2017; Accepted 1 June 2017; Published 9 July 2017

Academic Editor: Michele Fedel

Copyright © 2017 Hana Ighachane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Various unsaturated natural terpenes were selectively converted to the corresponding polychlorinated products in good yields using iron acetylacetonate in combination with nucleophilic cocatalyst. The synthesized compounds were evaluated for their in vitro antifungal activity. The antifungal bioassays showed that 2c and 2d possessed significant antifungal activity against Fusarium oxysporum f. sp. albedinis (Foa), Fusarium oxysporum f. sp. canariensis (Foc), and Verticillium dahliae (Vd).