Research Article | Open Access
Hoang Thanh Nguyen, Tuan Manh Nguyen, "Investigation of Magnetic Properties of Magnetic Poly (glycidyl methacrylate) Microspheres: Experimental and Theoretical", Advances in Materials Science and Engineering, vol. 2021, Article ID 6676453, 10 pages, 2021. https://doi.org/10.1155/2021/6676453
Investigation of Magnetic Properties of Magnetic Poly (glycidyl methacrylate) Microspheres: Experimental and Theoretical
Biocompatible magnetic poly (glycidyl methacrylate) microsphere is a novel nanocomposite with a myriad of promising bioapplications. Investigation of their characteristics by experimental analysis methods has also been carried out in the past. However, a survey of the magnetic anisotropy constant has not been mentioned and the influence of the poly (glycidyl methacrylate) polymer matrix on the Fe3O4 magnetite nanoparticles embedded inside has also not been discussed. Moreover, the accurate characterization of the magnetite nanoparticle size distribution remains challenging. In this paper, we present an effective approach was used to solve these problems. First of all, we combine both experiment and theory to estimate the effective magnetic anisotropy constant. Besides that, we implement an accurate method to determine magnetite nanoparticle size distribution in the magnetic poly (glycidyl methacrylate) microspheres composite nanomaterial.
During the last decade, Fe3O4 magnetite nanoparticles (MNPs) have been used in large number of fields, such as water treatment [1, 2], image diagnosis (magnetic resonance imaging (MRI) contrast agent) , cancer therapy (magnetic hyperthermia mediator, targeted drug, or gene delivery vehicle) [4, 5], separating cells, and capturing proteins/biomolecules . In these various biomedical applications, the essential issues must mention that the MNPs will be accumulated to large cluster under the different agents (strong magnetic dipole-dipole interaction, London–van der Waals attraction) . In order to improve bioavailability and minimize adverse effects, reduce the interparticle interaction, and control the size of the MNPs, the biocompatible polymers with their flexible functionalization are widely used as a matrix to embed the MNPs inside. Numerous polymer materials, both natural and synthetic, including chitosan , carboxymethyl cellulose , and dextran and polymethyl methacrylate (PMMA) [9, 10], have been investigated. Besides that, poly (glycidyl methacrylate) (PGMA) is also well known as a self-assembly, biodegradability, and pH sensitive polymer. The morphologies of PGMA derivatives are very unique, which is possible to create complex structures by way of self-assembly, such as micelle (spherical, cylindrical, etc.), reversal micelles (RM), capsule, and nanoparticle . In addition, the different triggers of internal and external factors, such as length and ratio of the hydrophobic fraction, pH, solvent composition, and temperature, can change their morphology . In addition, the advantage of the poly (glycidyl methacrylate) (PGMA) is being hydrophilic, as epoxy groups can be easily modified to carry a variety of reactive functional groups like NH2, COOH, and SH, which can be conjugated with biomolecules (antibodies, peptides, and drugs) , and stability (no aggregation) in various biological media. Therefore, the PGMA polymer microsphere embeds the MNPs showing great potential in nanomedicine, biotechnology, and molecular biology . However, this biocompatible polymer may interact with the surface atoms of the MNPs embedded inside and form a magnetically disordered layer or nonmagnetic layer . As a result, it contributes to the influence on the particles size distribution and the magnetic anisotropy, which are the crucial parameters in numerous applications .
The most successful methods at obtaining well-dispersed MNPs with narrow size distribution and uniform shape are microemulsion, polyol methods, and homogeneous precipitation or coprecipitation technique. The latter is the most common, easiest, versatile, convenient, and most efficient synthesis method used to obtain the MNPs, not only for laboratory purposes but also for industrial scale. The advantages of this method are that the reaction occurs at low temperatures and the obtained MNPs have fewer impurities compared to the microemulsion/solvothermal method . However, the downside is that the particle size distribution cannot be controlled [18, 19]. Anushree et al. used the coprecipitation method to synthesize the MNPs; at the same time the oxidation-precipitation method was also used to prepare carboxymethyl cellulose capped MNPs for various applications. These positive results were reported at [1, 20]. To fabricate the magnetic polymer microsphere materials, various formulas can be used. First of all, the most simple method that must be mentioned is that the magnetic particles and polymer materials are synthesized separately and then mixed together; thence the magnetic nanoparticles are formed inside the polymer matrix. Moreover, there are other common methods to obtain magnetic polymer beads, such as suspension polymerization, microemulsion polymerization, and free-emulsion polymerization in the presence of magnetic nanoparticles [11, 21, 22]. A disadvantage of these methods is that the magnetic microspheres obtained do not have a uniform size and shape. However, the method used in this work is simple, repeatable, and suitable for the preparation of monodisperse multifunctional microspheres with desired compact size.
As we have known, the magnetic properties of the MNPs are strongly affected by intrinsic parameters such as lattice constant, surface energy, and magnetic anisotropy, which depends on particle size and shape . Additionally, for the bioapplications like magnetic hyperthermia (MHT) applications, the magnetic anisotropy constant plays a key role [24–28]. However, the particle size determination methods of the MNPs embedded inside the magnetic PGMA microsphere are, for example, observing with transmission electron microscopy (TEM) or using Scherrer equation from X-ray diffraction (XRD) results, which have not been highly reliable and fully reflect essential information . Specifically, TEM images cannot observe fully a large amount of the MNPs embedded inside the PGMA microspheres. Therefore the particle size distribution is only local, which cannot be representative of the whole. Besides, the results obtained from the Scherrer equation are only average crystallite sizes, which can be considered as particle sizes when all particles are single crystal. Not only that, but also size determination from powder XRD, with the presence of the polymer matrix, rises the noise of the patterns, which has led to an increase in the false results. To the best knowledge of the authors, the magnetic anisotropy constant value, influence of PGMA polymer matrix to the MNPs, and the particle size distribution function determination of the MNPs inside the PGMA microspheres nanocomposite material are not studied so far. The aim of this study is to fabricate the magnetic poly (glycidyl methacrylate) (M-PGMA) microspheres for biomedical applications, which are prepared by in situ precipitation of the MNPs inside the PGMA polymer microspheres. On the one hand, experimental analysis methods like XRD, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and vibrating sample magnetometer (VSM) were used to investigate the characteristics of the M-PGMA microspheres. On the other hand, the theoretical approach, law of approach to saturation magnetization (LAS) principle, was also used to estimate the effective magnetic anisotropy constant (Keff) of the synthesized material at room temperature (300 K) and compared it to the obtained result from the relation of Keff with blocking temperature (TB) in zero-field-cooled/field-cooled (ZFC/FC) magnetization curves measurement. In addition, using the fitting of experimental magnetization curve data to the Langevin function enables determination of the median particle size, the corresponding standard deviation, and the particle size distribution function of the MNPs embedded inside the M-PGMA microspheres.
2. Materials and Methods
The materials used are monomer glycidyl methacrylate (GMA) (>97%) from Merck, 2,2′-azobis-isobutyronitrile (AIBN) from Sigma-Aldrich, poly (vinyl pyrrolidone) (PVP), ferric chloride hexahydrate (FeCl3.6H2O), ferrous chloride tetrahydrate (FeCl2.4H2O), ammonium hydroxide (25%), ethylene diamine (C2H4 (NH2)2, sodium hydroxide (NaOH), pure nitrogen gas (N2), and deionized (DI) water.
2.2. Fabricating the M-PGMA Microspheres
2.2.1. Polymerization of Monodisperse PGMA Microspheres
3 g PVP, 152.7 ml ethanol, and 13.5 ml DI water were put into the reaction flask and stirred, and 11.2 ml monomer glycidyl methacrylate (GMA) and 0.24 g AIBN were added to the flask. Nitrogen gas (N2) was pumped into the solution to remove the air from the system for 20 hours at 80°C and then it was refrigerated to 15°C. Then, we washed the sample several times with ethanol and DI water. Finally, the sample was dried by lyophilization.
Preparation of PGMA microspheres with amino groups (amino-PGMA): ethylene diamine was used to modify the chemical bond of PGMA microspheres, reacting with epoxy groups to form functional amino groups. Dried PGMA sample (7 g) was mixed with DI water (75 ml) and ethylenediamine (75 ml) at 80°C for 10 hours. After the reaction, the particles were separated and washed several times with DI water and then dried by lyophilization.
2.2.2. Preparation of M-PGMA Microspheres
The amino-PGMA dried sample (8 g) was dispersed into DI water (75 ml) and cooled down to 15°C. 0.2 M FeCl3.6H2O and 0.1 M FeCl2.4H2O in ratio 1 : 1 were dissolved in DI water (80 ml) and cooled down to 15°C and then mixed and stirred with the solution containing the amino-PGMA. Stirring was done at 800 rpm for about 30 minutes, and then the ammonia solution (25%) was added by pipette. The temperature is maintained at 80°C for 60 minutes for the continuation of the reaction. The particles were washed several times with DI water to remove excessive ammonia. Finally, the sample was dried by lyophilization.
Fabricating bare Fe3O4 MNPs under the same experimental conditions for comparison: Fe3O4 nanoparticles were synthesized using the coprecipitation method. 0.2 M FeCl3.6H2O and 0.1 M FeCl2.4H2O were dissolved in 80 ml of DI water, followed then by stirring for 20 minutes, dripping the ammonia solution (25%) by pipette, and continuously stirring for 60 minutes at 80°C for a complete occurrence of the reaction. The particles were washed several times with DI water and then dried by vacuum oven at 80°C in 8 hours.
Overview diagram of the experiment is shown in Figure 1.
2.3. The Law of Approach to Saturation (LAS) Principle
The law of approach to saturation (LAS) is a well-known mathematical model for describing the behavior of ferromagnets at strong magnetic fields (H ≫ Hc), which has the additional advantage that it is connected with the anisotropy constant of the material through one of the terms in the mathematical expression. The LAS describes the dependence of the magnetization (M) on the applied magnetic field (H) at a certain field, which is near the saturation magnetization Ms (H ≫ Hc). According to the LAS model, the magnetization near the saturation (Ms) can be expressed as follows :where Ms is the saturation magnetization, H is the applied magnetic field, and b is the parameter containing the magnetic anisotropy constant. The term a/H was interpreted as the result of the stress field and nonmagnetic inclusions, which was explained by Brown and Neel ; therefore, we can neglect the a/H term and the Hn terms with n > 2 in equation (1) . Equation (1) can be rewritten as
According to , the effective anisotropy constant of material can be estimated based on a relationship between parameter b and the Keff as follows:where Keff is the effective anisotropy constant of material and μ0 is the magnetic permeability.
2.4. Particle Size Determination from Magnetization Curve
As we have known, the magnetization curves of superparamagnetic nanoparticles (assuming that they are all of the same size) at room temperature (300 K) can be expressed by Langevin function :where b = μH/kBT, μ = MsbV is the particle magnetic moment, V is the particle volume, and Msb is the saturation magnetization of the bulk material. The saturation magnetization of superparamagnetic nanoparticles is Ms = ε Msb with ε being the volumetric particle packing fraction.
In practice, a magnetic nanoparticle system never has exactly the same size, which often follows a distribution function of particle sizes. The log-normal distribution is one of the most common distribution functions used to investigate the distribution of particle size . Many works have demonstrated that the log-normal size distribution is known to be the natural distribution of nanoparticle sizes [30, 36], which is written as follows:
Chantrell et al. have developed a numerical calculation method to determine the standard deviation (σ) and median particle diameter (D) from the magnetization curve at room temperature . Following that, the magnetization of a noninteracting superparamagnetic nanoparticle system with log-normal distribution of particle sizes in a certain applied magnetic field with weak magnetic anisotropy (KV << kBT) is given bywhere M (H) and Ms are the magnetization and saturation magnetization of superparamagnetic nanoparticle systems, respectively. L (x) is the Langevin function and f (y) = f (D) is the particle size distribution function of the system. is the median volume of particles with DmV representing the median diameter in the volume-weighted distribution. (y) is the volume-weighted distributions of the reduced diameters.
3. Results and Discussion
3.1. X-Ray Diffraction
The results of the X-ray phase analysis on the formation of samples were confirmed by X-ray diffraction (RD), obtained with the D8 Advance–Bruckner diffraction meter (Germany), using radiation with λ = 0.15406 nm in the range of 2 θ from 10° to 70° at room temperature (300 K).
Figure 2 shows the XRD pattern of samples: bare Fe3O4 MNPs (a in Figure 2) and M-PGMA (b in Figure 2). According to X-ray diffraction analysis (Figure 2), the diffraction peaks at lattice planes (2 2 0), (3 1 1), (4 0 0), (4 2 2), (5 1 1), and (4 4 0) are well matched with the standard XRD data for magnetite (JCPDS cards no. 75–0033). Moreover, the secondary phases are not found (in Figure 2b), which means the purified Fe3O4 MNPs were formed inside the PGMA polymer. However, as mentioned above, it has an approximately poor crystalline structure and peak intensity, caused by the influence of the amorphous PGMA polymer matrix.
The Scherrer equation is used for obtaining the average crystallite sizes (dXRD) of the samples:where K ˜ 0.9 is the Scherrer constant, β is the full width at half maxima of the strongest intensity diffraction peak, λ is the wavelength of radiation, and θ is the angle of the strongest peak. As a result, the crystallite size of the Fe3O4 MNPs in M-PGMA microspheres is = 3.8 (nm).
3.2. Fourier Transform Infrared Spectra
The chemical structure of synthesized samples was analyzed by Fourier transform infrared (FTIR) spectra on a Brucker Model IFS 28 spectrometer, which is also one of the most common techniques to identify the attachment of the polymer to the surface of the nanoparticles in nanocomposite materials. Figure 3 shows the FTIR spectra of two samples, PGMA (a in Figure 3) and M-PGMA (b in Figure 3), which are measured at room temperature (300 K) and in the wavenumber range of 400–4000 cm−1.
The FTIR spectra of the pure PGMA (a in Figure 3) show that the characteristic absorption bands observed at 1149 cm−1 and 846 cm−1, 993 cm−1 are related to symmetric oxirane ring and asymmetric oxirane ring, respectively. The carbonyl stretching vibrations in the PGMA appear at around 1730 cm−1. In addition, the dip observed at 3930 cm−1 is an alcoholic (O–H) stretching band. However, the FTIR spectra of the M-PGMA (b in Figure 3) showed that the dips located at 846 cm−1 and 993 cm−1 almost disappear, which are characteristic of the asymmetric oxirane ring (O–CH2–CH). Aside from that, the appearance of new absorption bands at 3399 cm−1, 1566 cm−1, and 1644 cm−1 demonstrates the presence of NH and NH2 groups, which is the result of modification of the PGMA by ethylenediamine. On the one hand, the presence of a new absorption band observed at 592 cm−1 corresponds to the vibration of the Fe–O stretching band, which is related to the existence of the Fe3O4 MNPs in the PGMA microspheres. On the other hand, the dip observed at 1130 cm−1 corresponding to (C–O) stretching vibration was shifted to a higher frequency, which has supposed that the PGMA polymer interacted with metal ions of the MNPs and immobilized them; a similar result was discussed in .
3.3. Microstructure and Morphology
In order to determine the particle size distribution and morphology of the synthesized material, scanning electron microscopy (SEM, JSM-5500) at a voltage of 15 kV was carried out. The particle size distribution of the M-PGMA microspheres was determined by measuring the diameter of 100 particles from the SEM images, sorting the sizes into a histogram, and then fitting the histogram data to a log-normal function, which was mentioned in equation (5).where D0 is the most probable particle diameter and σ is the width of the distribution. The median diameter 〈D〉SEM = D0·exp (σ2/2) and standard deviation of the distribution σSEM = 〈D〉SEM·[exp (σ2)–1]1/2.
The SEM images of the M-PGMA microspheres in Figure 4 clearly illustrated the spherical morphology, monodispersed and quite uniform in size. Besides that, their surface is quite rough, which is the result of modification surface of the PGMA by ethylenediamine and because of the presence of the Fe3O4 MNPs on their surface. The median size of the M-PGMA was <D>SEM = 1.36 (μm) and the corresponding standard deviation σSEM = 0.09 (μm).
3.4. Magnetic Characterization
Vibrating sample magnetometer (VSM) (MicroSense, USA, Model 029349-A01 6 MM) was used to analyze the magnetic properties of the synthesized sample at room temperature (300 K). A magnetic field of 15 kOe (1.19 × 106 A. m−1) was applied.
Figure 5 displays the magnetization curve of the M-PGMA at room temperature, which shows the superparamagnetic behavior. The values of the saturation magnetization (Ms), the remanent magnetization (Mr), and the coercive field (Hc) obtained from the magnetization curve are given in Table 1. When comparing with the bare magnetite nanoparticles and bulk magnetite material, which have the saturation magnetization Ms ∼ 90–100 emu/g , we noticed a strong decrease in the saturation magnetization of the synthesized material. Li et al. showed that not only the saturation magnetization (Ms) but also the remanent magnetization (Mr) and the coercive field (Hc) of the Fe3O4 MNPs system are highly influenced by the particle size and domain structure [17, 39]. The decrease of the magnetism parameters corresponds to decreasing particle size, regardless of the crystal structure and particle shape. According to the result obtained from the XRD pattern shown above, the crystallite size of the Fe3O4 MNPs in M-PGMA microspheres is dXRD = 3.8 (nm), which had led to reducing the amplitude of the magnetism parameters of the M-PGMA microspheres material. Besides that, the MNPs were immobilized in the PGMA polymer matrix, which formed the noninteracting magnetic nanoparticles system. This leads to a decrease in the dipole-dipole interaction between the MNPs, which contributes to a decrease in the saturation magnetization of the MNPs .
To measure zero-field-cooled (ZFC) magnetization curves, first of all, the sample is cooled from 300 K to 2 K (without the external applied magnetic field). Thereafter, a weak magnetic field (50 Oe) is applied, and the magnetic moment is recorded with an increase of temperature to obtain the ZFC curve. Under the same 50 Oe applied field but with a bit discrepancy, the field-cooled (FC) curve is measured during the sample cooling from room temperature (300 K) and magnetic moment is recorded with decreasing temperature.
Figure 6 displays the ZFC/FC magnetization curves of the sample measured at 50 (Oe). The blocking temperature (TB) was obtained directly from the ZFC M (T) magnetization curves, which is the top of the ZFC curve (TB = 10 K). Explaining for TB obtained at very low temperature, primary cause based on the blocking/unblocking mechanism of the MNPs is having single domain according to their sizes, smaller particles are easily unblocked at lower temperatures. We obtained K (T) from relation with TB as follows :where Keff (T) is the effective magnetic anisotropy constant at the blocking temperature (TB), kB is the Boltzmann constant, and V is the median volume of the particles. From that, we can calculate Keff = 1.9 × 104 (J/m3), which is close to the value reported by other studies for the bare Fe3O4 MNPs (particle size ∼ 5–8 nm) and larger than the bulk value for Fe3O4 (1.1 × 104 J/m3) [17, 42–49]. The primary cause is due to the dependence of the Keff on the particle size of MNPs (Keff increases as the size of MNPs decreases) which has been reported in [50, 51]. It is explained by the increase in surface anisotropy as the particle size decreases.
As mentioned above, the LAS principle is used to estimate the effective anisotropy constant (Keff) of the synthesized material. We use the reduced magnetization m = M/Ms, which as a function of 1/H2 was fitted linearly by equation (2) at high magnetic field strengths (7.96 × 105–1.19 × 106 A. m−1) (Figure 7). The obtained value b from the slope of the linear fitting is used to calculate Keff following equation (3). The estimated value of Keff of the M-PGMA microsphere at room temperature (300 K) is Keff (LAS) = 2.9 ± 0.6 × 103 (J/m3). Compared to Keff (TB) obtained above, it has a discrepancy in magnitude (displayed in Table 1), which can be understood based on the temperature dependence of magnetic anisotropy constant [52, 53]. As a result, the magnitude of Keff decreases with increasing temperature, and Keff (TB) obtained at 10 K is larger than Keff (LAS) obtained at 300 K.
3.5. Particle Size Distribution Function
When formed inside the M-PGMA microspheres, the MNPs are embedded and immobilized by the PGMA polymer matrix. Therefore, the MNPs system becomes a noninteracting magnetic nanoparticle system.
According to Chantrell et al., the magnetization of a noninteracting superparamagnetic system with a certain distribution of particle sizes (assuming all particles have sphere morphology and the form of the size distribution is log-normal distribution (equation (5)) at room temperature can be used to extract the particle size distribution. The experimentally measured magnetization curve data is used as mentioned above, which is fitted with the Langevin function for both low field data (initial susceptibility) and high field data (approach to saturation) to determine particle size distribution (Figure 8).
From the method of Chantrell et al. , we obtained the mean particle size (D) and the standard deviation (σD), respectively:where D is the mean particle size of the MNPs inside magnetic poly (glycidyl methacrylate) microspheres, χi is the initial susceptibility, Ms is the saturation magnetization of the particle, Msb is the saturation magnetization of the bulk material, T is the room temperature in Kelvin (300 K), H0 is the certain applied field at high field corresponding to the magnetization reduced to zero, and kB is the Boltzmann constant (1.38 × 10−23 J K−1).
From that, we obtain D = 3.76 (nm), σD = 0.77 (nm), and the particle size distribution function in Figure 8 (topset). This shows a narrow distribution in size, and the MNPs formed in the M-PGMA microspheres have a high uniformity in size, which is in excellent agreement with the average crystallite size determined by XRD (DXRD∼3.8 nm). It is demonstrated that the MNPs embedded inside the PGMA microsphere have a monocrystalline structure, with single domain. Besides that, the particle size distribution function has good agreement with the anisotropy energy barrier distribution displayed in the ZFC magnetization curve (lower part of the ZFC curve).
In this work, we have investigated the characteristics of the M-PGMA microspheres synthesized material by various experimental analysis methods. The synthesized magnetic microsphere material are monodispersed and quite uniform in size. Their median size and corresponding standard deviation were <D>SEM = 1.36 (μm) and σSEM = 0.09 (μm), respectively. The purified Fe3O4 MNPs were formed inside the PGMA polymer matrix, which has a monocrystalline structure, single domain, median particle size D = 3.76 (nm), corresponding standard deviation σD = 0.77 (nm), and particle size distribution function with a narrow distribution in size. Magnetic properties of the M-PGMA microspheres have also been investigated, which have superparamagnetic behavior and the magnetism parameters which are the saturation magnetization (Ms), the remanent magnetization (Mr), and the coercive field (Hc) are 5.16 (emu/g), 0.015 (emu/g), and 1.42 (Oe), respectively. Besides that, the Keff of the synthesized material was determined by two different methods: ZFC/FC measurement at 10 K (experimental method) and LAS principle at 300 K (theoretically approach) with the obtained values Keff (TB) = 1.9 ± 0.15 × 104 (J. m−3) and Keff (LAS) = 2.9 ± 0.6 × 103 (J. m−3), respectively. By investigating Keff, the influence of the PGMA polymer matrix on the MNPs embedded inside was considered. The PGMA polymer molecule interacted with surface atoms of the MNPs immobilized inside the M-PGMA microspheres forming a magnetically disordered shell or nonmagnetic layer. On the one hand, this decreased the magnetic core size of the MNPs. On the other hand, it had led to an increase in the surface anisotropy and a reduction of interparticle interactions (dipole-dipole interaction). As a result, it not only reduces the magnetic parameters including Ms, Mr, and Hc but also increases the magnetic anisotropy of the synthesized nanocomposite material.
The data used to support the findings of this study are included within the article.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
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