Anemia

A Molecular, Genetic, and Diagnostic Spotlight on Fanconi Anemia


Publishing date
08 Jun 2012
Status
Published
Submission deadline
09 Dec 2011

1Division of Molecular Biology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX  Amsterdam, The Netherlands

2Department of Medicine, Oregon Health & Science University, Portland, OR, USA

3School of Cancer and Enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK


A Molecular, Genetic, and Diagnostic Spotlight on Fanconi Anemia

Description

Fanconi anemia (FA) is a heritable disease characterized by bone marrow failure, congenital abnormalities, and a predisposition to develop malignancies, in particular acute myeloid leukemia and squamous cell carcinoma. So far, fifteen FA genes have been identified, the products of which operate in a molecular pathway that preserves genomic stability. The function of the FA proteins in DNA interstrand crosslink repair is emerging, novel FA mouse models that closely recapitulate hematological abnormalities observed in FA patients are available, and strategies for therapeutic intervention to prevent FA-associated hematopoietic symptoms and cancer onset have been outlined. We invite investigators to contribute original research articles as well as review articles that will stimulate the ongoing efforts to understand and treat FA on the basis of underlying molecular and cellular biology.

We are particularly interested in articles describing novel insights in FA protein function, the role of FA genes in hematopoietic stem and progenitor cells, therapeutic intervention by bone marrow transplantation, induced pluripotent stem cells, gene therapy, RNA interference, or small molecules, and the dysfunction of FA genes in sporadic hematological malignancies.Potential topics include, but are not limited to:

  • The elucidation of FA gene function in DNA repair, cell cycle regulation, or other molecular processes
  • The role of FA genes in stem cell biology
  • Advances in molecular diagnostics of FA
  • New insights in clinical features of FA
  • Strategies for therapeutic intervention to prevent bone marrow failure and cancer onset
  • FA gene mutations, silencing, and aberrant FA protein localization in sporadic malignancies
  • Management of cancer in FA patients

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ane/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 650730
  • - Editorial

A Molecular, Genetic, and Diagnostic Spotlight on Fanconi Anemia

Laura E. Hays | Stefan Meyer | Henri J. van de Vrugt
  • Special Issue
  • - Volume 2012
  • - Article ID 603253
  • - Research Article

Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing

Johan J. P. Gille | Karijn Floor | ... | Johan P. de Winter
  • Special Issue
  • - Volume 2012
  • - Article ID 425814
  • - Review Article

Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle

Tagrid Kaddar | Madeleine Carreau
  • Special Issue
  • - Volume 2012
  • - Article ID 865170
  • - Research Article

A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites

Yne de Vries | Nikki Lwiwski | ... | Hanne Meijers-Heijboer
  • Special Issue
  • - Volume 2012
  • - Article ID 783068
  • - Research Article

Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

Judith H. E. Verhagen-Oldenampsen | Jurgen R. Haanstra | ... | Marieke von Lindern
  • Special Issue
  • - Volume 2012
  • - Article ID 132856
  • - Research Article

Diagnosis of Fanconi Anemia: Mutation Analysis by Next-Generation Sequencing

Najim Ameziane | Daoud Sie | ... | Johan P. de Winter
  • Special Issue
  • - Volume 2012
  • - Article ID 323721
  • - Review Article

A DOG’s View of Fanconi Anemia: Insights from C. elegans

Martin Jones | Ann Rose
  • Special Issue
  • - Volume 2012
  • - Article ID 238731
  • - Research Article

Diagnosis of Fanconi Anemia: Chromosomal Breakage Analysis

Anneke B. Oostra | Aggie W. M. Nieuwint | ... | Johan P. de Winter
  • Special Issue
  • - Volume 2012
  • - Article ID 481583
  • - Review Article

Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics

Chelsea Jenkins | Jenny Kan | Maureen E. Hoatlin
  • Special Issue
  • - Volume 2012
  • - Article ID 349837
  • - Review Article

Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications

Stefan Meyer | Heidemarie Neitzel | Holger Tönnies
Anemia
 Journal metrics
Acceptance rate13%
Submission to final decision81 days
Acceptance to publication15 days
CiteScore2.800
Impact Factor-
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