Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy

Table 2

Effects of 0.5 mg/kg aristolochic acid sodium (AANa) treatment on inulin in rabbits (𝑛=10).

	Control	AANa treatment	𝑃 value
CL (mL/kg/min)	5.95 ± 1.79	0.89 ± 0.18	.014
𝑘(min^−1)	0.015 ± 0.001	0.007 ± 0.001	<.001
𝑉(mL/kg)	452.42 ± 173.38	130.91 ± 10.90	.089
AUC (μg × min/mL)	4644.96 ± 549.68	32246.76 ± 6531.83	.002

∗Data are expressed as the mean ± SE.
Parameters are described in the footnotes to Table 1.