Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl₄-Induced Hepatotoxicity in Mice

Table 5

Effect of polyherbal hepatoprotective formulations on biochemical serum parameters in CCl₄-induced hepatotoxicity.

Groups	Liver enzymes			Bilirubin (mg/dl)
	AST (IU/L)	ALT (IU/L)	ALP (IU/L)
Group 1	50.50 ± 2.30	30.70 ± 0.80	10.40 ± 0.50	0.30 ± 0.01
Group 2	140.30 ± 5.90^a	168.10 ± 2.90^a	34.40 ± 3.10^a	3.10 ± 0.10^a
Group 3	130.40 ± 3.90^bη	298.20 ± 3.10^b	33.70 ± 3.80^bη	0.90 ± 0.07^bη
Group 4	118.49 ± 4.20^b	414.40 ± 4.70^b	31.20 ± 2.00^bη	0.50 ± 0.07^b
Group 5	127.40 ± 4.10^bη	80.10 ± 3.50^b	27.30 ± 2.70^bη	1.00 ± 0.06^bη
Group 6	119.60 ± 4.80^b	51.30 ± 3.70^b	25.10 ± 2.10^b	0.70 ± 0.08^b
Group 7	121.36 ± 5.90^b	65.12 ± 4.30^b	26.40 ± 2.70^bη	0.70 ± 0.06^b
Group 8	77.00 ± 3.50^b	35.50 ± 3.80^b	21.80 ± 2.30^b	0.50 ± 0.03^b
Group 9	123.50 ± 3.80^bη	75.55 ± 2.70^b	27.00 ± 2.00^bη	1.00 ± 0.07^bη
Group 10	80.60 ± 3.20^b	49.20 ± 2.40^b	24.30 ± 2.20^b	0.70 ± 0.06^b

Each value is Mean ± S.E.M (n = 3). () designates statistically significant difference from the respective group, using Dunnett’s multiple comparison test (). (η) designates statistically no significant difference from the respective group using Dunnett’s multiple comparison test (). Group 1 = normal control, Group 2 = CCl₄ control, Group 3 = CCl₄+ 2.6 ml/kg/day Holyliv, Group 4 = CCl₄+ 5.2 ml/kg/day Holyliv, Group 5 = CCl₄+ 2.6 ml/kg/day Heptaliv, Group 6 = CCl₄+ 5.2 ml/kg/day Heptaliv, Group 7 = CCl₄+ 2.6 ml/kg/day Icturn, Group 8 = CCl₄+ 5.2 ml/kg/day Icturn, Group 9 = CCl₄+ 2.6 ml/kg/day J-Deenar, Group 10 = CCl₄+ 5.2 ml/kg/day J-Deenar.