Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl₄-Induced Hepatotoxicity in Mice

Table 6

Effect of pretreatment with polyherbal formulations on phenobarbitone-induced sleeping time of mice in CCl₄-induced hepatotoxicity.

Group	Phenobarbitone induced sleeping time (min)
Group 11	261.9 ± 5.7
Group 12	300.5 ± 10.3^a
Group 13	268.3 ± 9.8^bη
Group 14	225.7 ± 7.5^b
Group 15	260.5 ± 8.1^b
Group 16	196.8 ± 7.0^b
Group 17	220.7 ± 8.1^b
Group 18	188.4 ± 7.9^b
Group 19	230.7 ± 6.3^b
Group 20	190.4 ± 5.5^b

Each value is Mean ± S.E.M (n = 3). () designates statistically significant difference from the respective group using Dunnett’s multiple comparison test (). (η) designates statistically no significant difference from the respective group using Dunnett’s multiple comparison test (). Group 11 = normal control, Group 12 = CCl₄+ phenobarbitone control, Group 13 = CCl₄+ phenobarbitone + 2.6 ml/kg/day Holyliv, Group 14 = CCl₄+ phenobarbitone +5.2 ml/kg/day Holyliv, Group 15 = CCl₄+ phenobarbitone + 2.6 ml/kg/day Heptaliv, Group 16 = CCl₄+ phenobarbitone + 5.2 ml/kg/day Heptaliv, Group 17 = CCl₄+ phenobarbitone + 2.6 ml/kg/day Icturn, Group 18 = CCl₄ + phenobarbitone +5.2 ml/kg/day Icturn, Group 19 = CCl₄ + phenobarbitone +2.6 ml/kg/day J-Deenar, Group 20 = CCl₄+ phenobarbitone + 5.2 ml/kg/day J-Deenar.