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Advances in Urology
Volume 2012, Article ID 687230, 5 pages
http://dx.doi.org/10.1155/2012/687230
Review Article

Radical Prostatectomy and Intraoperative Radiation Therapy in High-Risk Prostate Cancer

1Division of Urology, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy
2Division of Radiotherapy, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy

Received 14 June 2011; Revised 12 September 2011; Accepted 30 September 2011

Academic Editor: Martin Spahn

Copyright © 2012 Giansilvio Marchioro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Intraoperative electron beam radiotherapy (IOERT) for prostate cancer (PC) is a radiotherapeutic technique, giving high doses of radiation during radical prostatectomy (RP). This paper presents the published treatment approaches for intraoperative radiotherapy analyzing functional outcome, morbidity, and oncological outcome in patients with clinical intermediate-high-risk prostate cancer. A systematic review of the literature was performed, searching PubMed and Web of Science. A “free text” protocol using the term intraoperative radiotherapy and prostate cancer was applied. Ten records were retrieved and analyzed including more than 150 prostate cancer patients treated with IOERT. IOERT represents a feasible technique with acceptable surgical time and minimal toxicity. A greater number of cases and longer follow-up time are needed in order to assess the long-term side effects and oncological outcome.