Advances in Urology

The Management of High-Risk Localized Prostate Cancer


Publishing date
15 Feb 2012
Status
Published
Submission deadline
15 Aug 2011

Lead Editor

1Department of Urology, University Hospitals Leuven, Leuven, Belgium

2Department of Urology and Pediatric Urology, University Hospital of Wuerzburg, Wuerzburg, Germany

3Section of Urology, Dipartimento di Discipline Medico-Chirurgiche, University of Studies of Torino, Turin, Italy


The Management of High-Risk Localized Prostate Cancer

Description

Prostate cancer (PCa) is one of the most important medical problems facing the male population. The complex management of the different stages of PCa, the improvement of detection techniques, and the increasing variety of treatment options led to a growing interest in a multidisciplinary approach for the diagnosis and treatment of PCa over the last few years. An example of a multidisciplinary approach in PCa can be found in the treatment of newly diagnosed high-risk PCa for which the objectives of treatment are two-fold. There is a need for local tumour control, as well as a need for treatment of microscopic metastases likely to be present but undetectable until disease progression. Therefore, the optimal treatment approach in these patients should be multimodal, but the exact combinations and timing of the treatment is still a point of discussion.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathways underlying high-risk PCa, the development of multimodal strategies to treat this condition, the development of reproducible methods to predict outcomes following treatment, and the evaluation of outcomes. We are particularly interested in articles describing the new modalities for clinical characterization of high-risk PCa, advances in molecular genetics and molecular diagnostics, new insights into the role of surgery, radiotherapy, hormonal therapy, and chemotherapy in the multimodal approach of the disease, and the future directions in diagnostics, outcome predictors, and novel treatment strategies of high-risk prostate cancer. Potential topics include, but are not limited to:

  • Defining high-risk localized PCa
  • Novel biomarkers in high-risk PCa: how to overcome the limitations of clinical risk classifications
  • New imaging modalities in the local staging of high-risk localized PCa
  • MRI in early detection of bone metastases
  • The role of radical prostatectomy in the treatment of high-risk localized PCa
  • The role of lymphadenectomy in high-risk PCa
  • The role of adjuvant radiotherapy after surgery in high-risk PCa
  • Combined radiotherapy and hormonal treatment in high-risk localized PCa
  • Potential feasibility of surgery in very aggressive settings (salvage surgery in radiorecurrent PCa, in hormone refractory PCa, in PSA over 100,etc.)
  • Is there a role for adjuvant hormonal therapy after surgery for high-risk PCa?
  • Is there a role for chemotherapy in the primary management of high-risk localized PCa?

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/au/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 980841
  • - Review Article

HDR Brachytherapy in the Management of High-Risk Prostate Cancer

Susan Masson | Raj Persad | Amit Bahl
  • Special Issue
  • - Volume 2012
  • - Article ID 612707
  • - Research Article

The Role of Adjuvant Hormonal Treatment after Surgery for Localized High-Risk Prostate Cancer: Results of a Matched Multiinstitutional Analysis

Maria Schubert | Steven Joniau | ... | Martin Spahn
  • Special Issue
  • - Volume 2012
  • - Article ID 687230
  • - Review Article

Radical Prostatectomy and Intraoperative Radiation Therapy in High-Risk Prostate Cancer

Giansilvio Marchioro | Alessandro Volpe | ... | Carlo Terrone
  • Special Issue
  • - Volume 2012
  • - Article ID 706309
  • - Research Article

Complications and Functional Results of Surgery for Locally Advanced Prostate Cancer

S. G. Joniau | A. A. Van Baelen | ... | H. P. Van Poppel
  • Special Issue
  • - Volume 2012
  • - Article ID 164263
  • - Clinical Study

Oncologic Outcomes of Surgery in T3 Prostate Cancer: Experience of a Single Tertiary Center

D. Milonas | G. Smailyte | M. Jievaltas
  • Special Issue
  • - Volume 2012
  • - Article ID 368528
  • - Clinical Study

Clinical Results after High-Dose Intensity-Modulated Radiotherapy for High-Risk Prostate Cancer

Valérie Fonteyne | Nicolaas Lumen | ... | Gert De Meerleer
  • Special Issue
  • - Volume 2012
  • - Article ID 641689
  • - Review Article

Management of High-Risk Localized Prostate Cancer

Ariel E. Marciscano | Matthew E. Hardee | Nicholas Sanfilippo
  • Special Issue
  • - Volume 2012
  • - Article ID 893193
  • - Review Article

Modern Detection of Prostate Cancer's Bone Metastasis: Is the Bone Scan Era Over?

Bertrand Tombal | Frederic Lecouvet
  • Special Issue
  • - Volume 2012
  • - Article ID 410246
  • - Research Article

Radical Prostatectomy: An Option for High-Risk Prostate Cancer

S. Rausch | C. Schmitt | T. Kälble
  • Special Issue
  • - Volume 2012
  • - Article ID 983058
  • - Review Article

Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer

Anthony Van Baelen | Nicolas Mottet | ... | Steven Joniau
Advances in Urology
 Journal metrics
Acceptance rate7%
Submission to final decision74 days
Acceptance to publication20 days
CiteScore1.290
Impact Factor-
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