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Advances in Virology
Volume 2011 (2011), Article ID 965689, 5 pages
Research Article

Sexual Transmission of XMRV: A Potential Infection Route

1Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
2Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA
3Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Bangkok 10700, Thailand
4Abbott Diagnostics, Emerging Pathogens and Virus Discovery, Abbott Park, IL 60064, USA
5Glickman Urological and Kidney Institute and LRI, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
6Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA

Received 27 April 2011; Accepted 25 May 2011

Academic Editor: Arifa S. Khan

Copyright © 2011 Prachi Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although XMRV dissemination in humans is a matter of debate, the prostate of select patients seem to harbor XMRV, which raises questions about its potential route of transmission. We established a model of infection in rhesus macaques inoculated with XMRV. In spite of the intravenous inoculation, all infected macaques exhibited readily detectable XMRV signal in the reproductive tract of all 4 males and 1 female during both acute and chronic infection stages. XMRV showed explosive growth in the acini of prostate during acute but not chronic infection. In seminal vesicles, epididymis, and testes, XMRV protein production was detected throughout infection in interstitial or epithelial cells. In the female monkey, epithelial cells in the cervix and vagina were also positive for XMRV gag. The ready detection of XMRV in the reproductive tract of male and female macaques infected intravenously suggests the potential for sexual transmission for XMRV.