BioMed Research International

BioMed Research International / 2004 / Article
Special Issue

Anthocyanins—More Than Nature's Colour

View this Special Issue

Research article | Open Access

Volume 2004 |Article ID 380728 | https://doi.org/10.1155/S1110724304403106

Roland Bitsch, Michael Netzel, Thomas Frank, Gabriele Strass, Irmgard Bitsch, "Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine", BioMed Research International, vol. 2004, Article ID 380728, 6 pages, 2004. https://doi.org/10.1155/S1110724304403106

Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine

Received03 Mar 2004
Revised24 May 2004
Accepted15 Jun 2004

Abstract

In a comparative study, 9 healthy volunteers ingested a single oral dose of 400 mL red grape juice or red wine with dose-adjusted anthocyanin content (283.5 mg or 279.6 mg, resp.) in crossover. The content of anthocyanin glucosides was detected in plasma and urinary excretion. Additionally, the plasmatic antioxidant activity was assessed after intake. Based on the plasma content, biokinetic criteria of the single anthocyanins were calculated, such as AUC, cmax, tmax, and the elimination rate t1/2. The urinary excretion of total anthocyanins differed significantly and amounted to 0.18% (red wine) and 0.23% (red grape juice) of the administered dose. Additionally, the plasmatic antioxidant activity increased to higher levels after juice ingestion compared to wine. The intestinal absorption of the anthocyanins of red grape juice seemed to be improved compared to red wine, suggesting a possible synergistic effect of the glucose content of the juice. The improved absorption resulted in an enhanced plasmatic bioactivity.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views192
Downloads1050
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.