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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 202918, 9 pages
http://dx.doi.org/10.1155/2010/202918
Research Article

Features of Recent Codon Evolution: A Comparative Polymorphism-Fixation Study

1Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
2Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
3Bioinformatics Resource Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37203, USA
4Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA

Received 14 March 2010; Accepted 31 March 2010

Academic Editor: Momiao Xiong

Copyright © 2010 Zhongming Zhao and Cizhong Jiang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1. Sequence composition at each codon position.

Supplementary Figure 1. Normalized difference of amino acid changes (gain or loss) at the polymorphic and fixed sites in amino-acid coding regions. The normalized difference for an amino acid is defined as the difference of the number of mutations removing the amino acid from creating the amino acid and divided by the total number of mutations in the amino acid. Amino acids are ordered in their temporal order in the genetic code according to Trifonov [1]. The ancient amino acids are at the left while the late ones are at the right.

Supplementary Figure 2. Normalized difference of codon changes (gain or loss) at the polymorphic and fixed sites in amino-acid coding regions. The normalized difference for a codon is defined as the difference of the number of mutations removing the codon from creating the codon and divided by the total number of mutations in the codon. Codons are ordered in the amino acid temporal order in the genetic code according to Trifonov [1]. The ancient amino acids are at the left while the late ones are at the right. Within each amino acid, the early-coming codons are at the left while the late-coming codons are at the right.

  1. Supplementary Material