BioMed Research International

Next-Generation Sequencing


Publishing date
15 Aug 2010
Status
Published
Submission deadline
15 Feb 2010

Lead Editor

1Human Genetics Center, The University of Texas School of Public Health, Austin, TX, USA

2Department of Genetics, University of Georgia, Life Sciences BLDG, Ahtens, GA 30602, USA

3Vanderbilt-Ingram Cancer Center (VICC), Departments of Biomedical Informatics and Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA

4Human Genome Sequence Center, Baylor College of Medicine, Houston, TX, USA


Next-Generation Sequencing

Description

Next-generation DNA sequencing platforms including 4D4 life sciences (Roche), illumina 1G genome analysis system, applied biosystems SOLiD sequencing, and Helicos GSS sequencing can effectively detect the entire spectrum of genomic variation and provide a powerful tool for systematic exploration of the universe of variants and interactions in the entire genome. Next-generation DNA sequencing will revolutionize research in biotechnology and medicine.

This special issue will mainly focus on application of next-generation DNA sequencing to biomedical research. We invite authors to present original research articles as well as reviews and opinions, on the following, but not limited to, topics:

  • Next-generation sequencing methods: comparisons of costs, accuracy, and productivity of next-generation sequencing machines including 454, Solexa, SOLiD, and their selection in the project
  • Next-generation sequencing or SNP association mapping? Balancing costs and benefits
  • Pattern and causes of sequencing errors, error rates of three major sequencing machines: 454, Solexa, and SOLiD, and impact of sequencing accuracy on genetic variant discovery, population genetics, and association studies of complex diseases
  • Methods for sequencing error correction
  • SNP and structural variation (e.g., CNV, Indel) discovery by next-generation sequencing
  • Gene expression and miRNA expression with next-generation sequencing
  • Next-generation sequencing for personal medicine, for example, diagnosis and treatment
  • Bioinformatics for next-generation sequencing including alignment, assembly, and base calling
  • Methods and algorithms for dealing massive datasets generated by next-generation sequencing: reduction methods for high-dimensional genomic data
  • Statistical methods for testing association of full spectrum of genetic variants discovered by next-generation sequencing with complex diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 370710
  • - Editorial

Next-Generation Sequencing

Momiao Xiong | Zhongming Zhao | ... | Fuli Yu
  • Special Issue
  • - Volume 2010
  • - Article ID 134232
  • - Research Article

Serine Protease Variants Encoded by Echis ocellatus Venom Gland cDNA: Cloning and Sequencing Analysis

S. S. Hasson | R. A. Mothana | ... | A. A. Al-Jabri
  • Special Issue
  • - Volume 2010
  • - Article ID 867517
  • - Research Article

Global Egr1-miRNAs Binding Analysis in PMA-Induced K562 Cells Using ChIP-Seq

Wei Wang | Dequang Zhou | ... | Zuhong Lu
  • Special Issue
  • - Volume 2010
  • - Article ID 853916
  • - Review Article

Uncovering the Complexity of Transcriptomes with RNA-Seq

Valerio Costa | Claudia Angelini | ... | Alfredo Ciccodicola
  • Special Issue
  • - Volume 2010
  • - Article ID 425939
  • - Research Article

Identification of microRNAs Involved in the Host Response to Enterovirus 71 Infection by a Deep Sequencing Approach

Lunbiao Cui | Xiling Guo | ... | Hua Wang
  • Special Issue
  • - Volume 2010
  • - Article ID 915980
  • - Research Article

High-Throughput Sequencing of MicroRNAs in Adenovirus Type 3 Infected Human Laryngeal Epithelial Cells

Yuhua Qi | Jing Tu | ... | Zuhong Lu
  • Special Issue
  • - Volume 2010
  • - Article ID 202918
  • - Research Article

Features of Recent Codon Evolution: A Comparative Polymorphism-Fixation Study

Zhongming Zhao | Cizhong Jiang
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision77 days
Acceptance to publication54 days
CiteScore2.410
Impact Factor2.197
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