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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 238080, 10 pages
Review Article

Mechanisms of the Regulation of the Intestinal Exchanger NHE3

1Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
2Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA

Received 21 July 2009; Accepted 11 September 2009

Academic Editor: Kenichiro Kitamura

Copyright © 2010 Peijian He and C. Chris Yun. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A major of absorptive process in the proximal part of intestine and kidney is electroneutral exchange of and by exchanger type 3 (NHE3). During the past decade, significant advance has been achieved in the mechanisms of NHE3 regulation. A bulk of the current knowledge on exchanger regulation is based on heterologous expression of mammalian exchangers in exchanger deficient fibroblasts, renal epithelial, and intestinal epithelial cells. Based on the reductionist's approach, an understanding of NHE3 regulation has been greatly advanced. More recently, confirmations of in vitro studies have been made using animals deficient in one or more proteins but in some cases unexpected findings have emerged. The purpose of this paper is to provide a brief overview of recent progress in the regulation and functions of NHE3 present in the luminal membrane of the intestinal tract.