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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 362524, 8 pages
Research Article

Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent

1College of Veterinary Medicine, China Agricultura University, Beijing 100193, China
2Department of Medical and Molecular Biosciences, University of Technology Sydney, Broadway, Sydney, NSW 2007, Australia
3Xiangya Hospital, Center for Molecular Medicine of Central South University, Changsha 410078, China

Received 26 January 2010; Revised 10 May 2010; Accepted 9 June 2010

Academic Editor: Schwan William

Copyright © 2010 Juan Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. M. Neuhauser, R. A. Weinstein, R. Rydman, L. H. Danziger, G. Karam, and J. P. Quinn, “Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use,” Journal of the American Medical Association, vol. 289, no. 7, pp. 885–888, 2003. View at Publisher · View at Google Scholar
  2. M. J. Richards, J. R. Edwards, D. H. Culver, and R. P. Gaynes, “Nosocomial infections in medical intensive care units in the United States: National Nosocomial Infections Surveillance System,” Critical Care Medicine, vol. 27, no. 5, pp. 887–892, 1999. View at Publisher · View at Google Scholar
  3. P. Richard, R. Le Floch, C. Chamoux, M. Pannier, E. Espaze, and H. Richet, “Pseudomonas aeruginosa outbreak in a burn unit: role of antimicrobials in the emergence of multiply resistant strains,” Journal of Infectious Diseases, vol. 170, no. 2, pp. 377–383, 1994. View at Google Scholar
  4. C.-I. Kang, S.-H. Kim, and S.-H. Kim, “Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome,” Clinical Infectious Diseases, vol. 37, no. 6, pp. 745–751, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. O. Piazza, A. Iasiello, C. Papaianni, E. De Robertis, G. Servillo, F. Rossano, and R. Tufano, “Incidence of antimicrobial-resistant ventilator associated pneumonia: an eighteen-month survey,” Panminerva Medica, vol. 47, no. 4, pp. 265–267, 2005. View at Google Scholar
  6. C. Llanes, C. Neuwirth, F. El Garch, D. Hocquet, and P. Plésiat, “Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 β-lactamase,” Clinical Microbiology and Infection, vol. 12, no. 3, pp. 270–278, 2006. View at Publisher · View at Google Scholar · View at PubMed
  7. S. A. Murray and D. R. Snydman, “Investigation of an epidemic of multi-drug resistant Pseudomonas aeruginosa,” Infection Control, vol. 3, no. 6, pp. 456–460, 1982. View at Google Scholar
  8. L. Pagani, C. Colinon, and C. Colinon, “Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-β-lactamase,” Journal of Clinical Microbiology, vol. 43, no. 8, pp. 3824–3828, 2005. View at Publisher · View at Google Scholar · View at PubMed
  9. J.-P. Pirnay, D. De Vos, and D. De Vos, “Molecular epidemiology of Pseudomonas aeruginosa colonization in a burn unit: persistence of a multidrug-resistant clone and a silver sulfadiazine-resistant clone,” Journal of Clinical Microbiology, vol. 41, no. 3, pp. 1192–1202, 2003. View at Publisher · View at Google Scholar
  10. R. Bax, N. Mullan, and J. Verhoef, “The millennium bugs—the need for and development of new antibacterials,” International Journal of Antimicrobial Agents, vol. 16, no. 1, pp. 51–59, 2000. View at Publisher · View at Google Scholar
  11. R. M. K. Dale, G. Schnell, and J. P. Wong, “Therapeutic efficacy of “nubiotics” against burn wound infection by Pseudomonas aeruginosa,” Antimicrobial Agents and Chemotherapy, vol. 48, no. 8, pp. 2918–2923, 2004. View at Publisher · View at Google Scholar · View at PubMed
  12. B. J. Yuan, M. Y. Liao, and B. Li, Drug Toxicological Methods and Techniques, Chemical Industry Publisher, Beijing, China, 1st edition, 2007.
  13. J. P. O'Neill and A. W. Hsie, “Phenotypic expression time of mutagen induced 6-thioguanine resistance in Chinese hamster ovary cells (CHO/HGPRT system),” Mutation Research, vol. 59, no. 1, pp. 109–118, 1979. View at Google Scholar
  14. J. P. O'Neill, P. A. Brimer, R. Machanoff, G. P. Hirsch, and A. W. Hsie, “A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): development and definition of the system,” Mutation Research, vol. 45, no. 1, pp. 91–101, 1977. View at Google Scholar
  15. J. P. O'Neill, R. Machanoff, J. R. San Sebastian, and A. W. Hsie, “Cytotoxicity and mutagenicity of dimethylnitrosamine in mammalian cells (CHO/HGPRT system): enhancement by calcium phosphate,” Environmental Mutagenesis, vol. 4, no. 1, pp. 7–18, 1982. View at Google Scholar
  16. M. Hayashi, R. R. Tice, and R. R. Tice, “In vivo rodent erythrocyte micronucleus assay,” Mutation Research, vol. 312, no. 3, pp. 293–304, 1994. View at Publisher · View at Google Scholar