Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 523481, 15 pages
http://dx.doi.org/10.1155/2011/523481
Review Article

Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock

Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital/Harvard Medical School, 165 Cambridge Street, Suite 810, Boston, MA 02114, USA

Received 20 July 2010; Accepted 16 November 2010

Academic Editor: Patrick Matthias

Copyright © 2011 Yongqing Li and Hasan B. Alam. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [50 citations]

The following is the list of published articles that have cited the current article.

  • Guang Jin, Dirk Bausch, Thomas Knightly, Zhengcai Liu, Yongqing Li, Baoling Liu, Jennifer Lu, Wei Chong, George C. Velmahos, and Hasan B. Alam, “Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro,” Surgery, vol. 150, no. 3, pp. 429–435, 2011. View at Publisher · View at Google Scholar
  • Hasan B. Alam, and George C. Velmahos, “New Trends in Resuscitation,” Current Problems in Surgery, vol. 48, no. 8, pp. 531–564, 2011. View at Publisher · View at Google Scholar
  • H. B. Alam, “Translational barriers and opportunities for emergency preservation and resuscitation in severe injuries,” British Journal of Surgery, vol. 99, no. S1, pp. 29–39, 2011. View at Publisher · View at Google Scholar
  • K. Søreide, “Strengthening the trauma chain of survival,” British Journal of Surgery, vol. 99, no. S1, pp. 1–3, 2011. View at Publisher · View at Google Scholar
  • Ashley R. Kochanek, Eugene Y. Fukudome, Yongqing Li, Eleanor J. Smith, Baoling Liu, George C. Velmahos, Marc deMoya, David King, and Hasan B. Alam, “Histone Deacetylase Inhibitor Treatment Attenuates MAP Kinase Pathway Activation and Pulmonary Inflammation Following Hemorrhagic Shock in a Rodent Model,” Journal of Surgical Research, vol. 176, no. 1, pp. 185–194, 2012. View at Publisher · View at Google Scholar
  • Wei Chong, David R. King, Andrew L. Kung, Hasan B. Alam, Yongqing Li, Baoling Liu, Zhengcai Liu, Ting Zhao, Diane R. Wonsey, Changmin Chen, George C. Velmahos, and Marc A. DeMoya, “Anti-inflammatory properties of histone deacetylase inhibitors: A mechanistic study,” Journal of Trauma and Acute Care Surgery, vol. 72, no. 2, pp. 347–354, 2012. View at Publisher · View at Google Scholar
  • Joseph G. Sinkovics, “Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens, and microRNA/DNA interactions (Review),” International Journal Of Oncology, vol. 40, no. 2, pp. 305–349, 2012. View at Publisher · View at Google Scholar
  • Wei Chong, Yongqing Li, Baoling Liu, Ting Zhao, Eugene Y. Fukudome, Zhengcai Liu, William M. Smith, George C. Velmahos, Marc A. deMoya, and Hasan B. Alam, “Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages,” Journal of Surgical Research, vol. 178, no. 2, pp. 851–859, 2012. View at Publisher · View at Google Scholar
  • Amie J. Dirks-Naylor, Ngan T. K. Tran, Sendra Yang, Raean Mabolo, and Samir A. Kouzi, “The effects of acute doxorubicin treatment on proteome lysine acetylation status and apical caspases in skeletal muscle of fasted animals,” Journal of Cachexia Sarcopenia and Muscle, vol. 4, no. 3, pp. 239–243, 2013. View at Publisher · View at Google Scholar
  • Marlin Wayne Causey, Seth Miller, Zachary Hoffer, James Hempel, Jonathan Stallings, Guang Jin, Hasan Alam, and Matthew Martin, “Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury,” Journal of Surgical Research, 2013. View at Publisher · View at Google Scholar
  • Zhengcai Liu, Hasan B. Alam, Yongqing Li, Baoling Liu, Danielle K. Deperalta, Ting Zhao, Wei Chong, Xiuzhen Duan, Peter Zhou, and George C. Velmahos, “Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model,” Journal of Trauma and Acute Care Surgery, vol. 74, no. 4, pp. 991–998, 2013. View at Publisher · View at Google Scholar
  • Daniel W. Nelson, Christopher R. Porta, Derek P. McVay, Shashikumar K. Salgar, and Matthew J. Martin, “Effects of histone deacetylase inhibition on 24-hour survival and end-organ injury in a porcine trauma model: A prospective, randomized trial,” Journal of Trauma and Acute Care Surgery, vol. 75, no. 6, pp. 1031–1039, 2013. View at Publisher · View at Google Scholar
  • Toshiaki Iba, Miwa Murai, Isao Nagaoka, and Yoko Tabe, “Neutrophil extracellular traps, damage-associated molecular patterns, and cell death during sepsis,” Acute Medicine & Surgery, 2013. View at Publisher · View at Google Scholar
  • Toshiaki Iba, Miwa Murai, Isao Nagaoka, and Yoko Tabe, “Neutrophil extracellular traps (NETs), damage-associated molecular patterns (DAMPs) and cell-death during sepsis,” Nihon Kyukyu Igakukai Zasshi, vol. 24, no. 10, pp. 827–836, 2013. View at Publisher · View at Google Scholar
  • Amie J Dirks-Naylor, Samir A Kouzi, Joseph D Bero, Ngan Tk Tran, Sendra Yang, and Raean Mabolo, “Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptotic environment.,” World journal of biological chemistry, vol. 5, no. 3, pp. 377–86, 2014. View at Publisher · View at Google Scholar
  • Cecilie Heerdegen Jepsen, Marc A. deMoya, Anders Perner, Martin Sillesen, Sisse R. Ostrowski, Hasan B. Alam, and Pär I. Johansson, “Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury,” Journal of Trauma and Acute Care Surgery, vol. 77, no. 2, pp. 292–297, 2014. View at Publisher · View at Google Scholar
  • Guang Jin, Baoling Liu, Zerong You, Ted Bambakidis, Simone E. Dekker, Jake Maxwell, Ihab Halaweish, Durk Linzel, and Hasan B. Alam, “Development of a novel neuroprotective strategy: Combined treatment with hypothermia and valproic acid improves survival in hypoxic hippocampal cells,” Surgery, vol. 156, no. 2, pp. 221–228, 2014. View at Publisher · View at Google Scholar
  • S. Schwertheim, K. Worm, K. W. Schmid, and S-Y. Sheu-Grabellus, “Valproic Acid Downregulates NF-kB p50 Activity and IRAK-1 in a Progressive Thyroid Carcinoma Cell Line,” Hormone and Metabolic Research, vol. 46, no. 03, pp. 181–186, 2014. View at Publisher · View at Google Scholar
  • Zhengcai Liu, Yongqing Li, Wei Chong, Danielle K. Deperalta, Xiuzhen Duan, Baoling Liu, Ihab Halaweish, Peter Zhou, and Hasan B. Alam, “Creating a Prosurvival Phenotype Through a Histone Deacetylase Inhibitor in a Lethal Two-Hit Model,” Shock, vol. 41, no. 2, pp. 104–108, 2014. View at Publisher · View at Google Scholar
  • D. T. Martin, and M. A. Schreiber, “Modern resuscitation of hemorrhagic shock: what is on the horizon?,” European Journal Of Trauma And Emergency Surgery, vol. 40, no. 6, pp. 641–656, 2014. View at Publisher · View at Google Scholar
  • Yili Zhao, Peter Zhou, Baoling Liu, Ted Bambakidis, Ralph Mazitschek, Hasan B. Alam, and Yongqing Li, “Protective Effect of SAHA against LPS-induced Liver Damage in Rodents,” Journal of Surgical Research, 2014. View at Publisher · View at Google Scholar
  • Zhou, Wu, Alam, and Li, “Histone cleavage as a mechanism for epigenetic regulation: Current insights and perspectives,” Current Molecular Medicine, vol. 14, no. 9, pp. 1164–1172, 2014. View at Publisher · View at Google Scholar
  • Wei He, Peter Zhou, Zhigang Chang, Baoling Liu, Xuefeng Liu, Yanming Wang, Yongqing Li, and Hasan B. Alam, “Inhibition of Peptidylarginine Deiminase Attenuates Inflammation and Improves Survival in a Rat Model of Hemorrhagic Shock,” Journal of Surgical Research, 2015. View at Publisher · View at Google Scholar
  • Alted López, “Are the paradigms in trauma disease changing?,” Medicina Intensiva, vol. 39, no. 6, pp. 375–382, 2015. View at Publisher · View at Google Scholar
  • E. Alted López, “Are the paradigms in trauma disease changing?,” Medicina Intensiva (English Edition), 2015. View at Publisher · View at Google Scholar
  • Shu-Yu Wu, Shih-En Tang, Fu-Chang Ko, Geng-Chin Wu, Kun-Lun Huang, and Shi-Jye Chu, “Valproic Acid Attenuates Acute Lung Injury Induced by Ischemia-Reperfusion in Rats,” Anesthesiology, vol. 122, no. 6, pp. 1327–1337, 2015. View at Publisher · View at Google Scholar
  • E. Alted López, “¿Están cambiando nuestros paradigmas en la enfermedad traumática?,” Medicina Intensiva, 2015. View at Publisher · View at Google Scholar
  • Amanda V. Steckert, Clarissa M. Comim, Dhébora M. Dall Igna, Diogo Dominguini, Bruna P. Mendonça, Felipe Ornell, Gabriela D. Colpo, Carolina Gubert, Flávio Kapczinski, Tatiana Barichello, João Quevedo, and Felipe Dal-Pizzol, “Effects of sodium butyrate on aversive memory in rats submitted to sepsis,” Neuroscience Letters, 2015. View at Publisher · View at Google Scholar
  • Hsian-He Hsu, Shu-Yu Wu, Shih-En Tang, Geng-Chin Wu, Min-Hui Li, Kun-Lun Huang, and Shi-Jye Chu, “Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A,” International Immunopharmacology, 2015. View at Publisher · View at Google Scholar
  • Zhigang Chang, Yongqing Li, Wei He, Baoling Liu, Ihab Halaweish, Ted Bambakidis, Yingjian Liang, and Hasan B. Alam, “Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock,” Journal Of Trauma And Acute Care Surgery, vol. 79, no. 6, pp. 905–910, 2015. View at Publisher · View at Google Scholar
  • Ranran Li, Adnan Aslan, Rui Yan, Rianne M. Jongman, Jill Moser, Peter J. Zwiers, Henk E. Moorlag, Jan G. Zijlstra, Grietje Molema, and Matijs van Meurs, “Histone Deacetylase Inhibition and I kappa B Kinase/Nuclear Factor-kappa B Blockade Ameliorate Microvascular Proinflammatory Responses Associated With,” Critical Care Medicine, vol. 43, no. 12, pp. E567–E580, 2015. View at Publisher · View at Google Scholar
  • Zhigang Chang, Hasan B. Alam, Yongqing Li, Baoling Liu, Ihab Halaweish, Ted Bambakidis, Baihong Pan, Vahagn C. Nikolian, Patrick Georgoff, Wei He, Xiuzhen Duan, and Yingjian Liang, “Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock,” Journal of Trauma and Acute Care Surgery, vol. 81, no. 3, pp. 512–519, 2016. View at Publisher · View at Google Scholar
  • So-Jin Kim, Jin-Sook Park, Do-Won Lee, and Sun-Mee Lee, “Trichostatin A Protects Liver against Septic Injury through Inhibiting Toll-Like Receptor Signaling,” Biomolecules & Therapeutics, vol. 24, no. 4, pp. 387–394, 2016. View at Publisher · View at Google Scholar
  • Yukio Imamura, Nao Yoshikawa, Yuki Murkami, Satoko Mitani, Naoya Matsumoto, Hisatake Matsumoto, Tomoki Yamada, Kazuma Yamakawa, Junichiro Nakagawa, Hiroshi Ogura, Takeshi Shimazu, and Takashi Jin, “Effect Of Histone Acetylation On N-Methyl-D-Aspartate 2B Receptor Subunits And Interleukin-1 Receptors In Association With Nociception-Related Somatos,” Shock, vol. 45, no. 6, pp. 660–667, 2016. View at Publisher · View at Google Scholar
  • Chunyan Wang, Yu Wang, Zhixin Qiao, Qiyuan Kuai, Yanbing Wang, Xuanlin Wang, Min He, Weijing Li, Yuezhong He, Suping Ren, and Qun Yu, “Valproic acid-mediated myocardial protection of acute hemorrhagic rat via the BCL-2 pathway,” Journal Of Trauma And Acute Care Surgery, vol. 80, no. 5, pp. 812–818, 2016. View at Publisher · View at Google Scholar
  • Ting Zhao, Yongqing Li, Baoling Liu, Baihong Pan, Xin Cheng, Patrick Georgoff, and Hasan B. Alam, “Inhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic model,” Journal of Trauma and Acute Care Surgery, vol. 80, no. 1, pp. 34–41, 2016. View at Publisher · View at Google Scholar
  • Vahagn C. Nikolian, Hasan B. Alam, Baihong Pan, Isabel S. Dennahy, Patrick E. Georgoff, Xiuzhen Duan, Baoling Liu, Yongqing Li, Tomaz Mesar, Xizi Wu, and Michael J. Duggan, “Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock,” Inflammation, vol. 40, no. 4, pp. 1264–1274, 2017. View at Publisher · View at Google Scholar
  • Marie Warren, Kumar Subramani, Richard Schwartz, and Raghavan Raju, “Mitochondrial dysfunction in rat splenocytes following hemorrhagic shock,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017. View at Publisher · View at Google Scholar
  • George Kasotakis, Manuel D. Galvan, Paw Osathanugrah, Neerav Dharia, Lauren Bufe, Zachary Breed, Joseph P. Mizgerd, and Daniel G. Remick, “Timing of valproic acid in acute lung injury: prevention is the best therapy?,” Journal of Surgical Research, vol. 220, pp. 206–212, 2017. View at Publisher · View at Google Scholar
  • Hasan B. Alam, Manjunath P. Pai, Mohamed H. Ghandour, Ashok Srinivasan, Vahagn C. Nikolian, Yongqing Li, Patrick E. Georgoff, Isabel S. Dennahy, Kiril Chtraklin, Hassan Eidy, and Yanyan Han, “Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma,” Journal of Trauma and Acute Care Surgery, vol. 83, no. 6, pp. 1066–1073, 2017. View at Publisher · View at Google Scholar
  • W -I Liao, W -C Chien, C -H Chung, J -C Wang, T -T Chung, S -J Chu, and S -H Tsai, “Valproic acid attenuates the risk of acute respiratory failure in patients with subarachnoid hemorrhage,” QJM: An International Journal of Medicine, vol. 111, no. 2, pp. 89–96, 2017. View at Publisher · View at Google Scholar
  • Zhangsheng Yang, Mikulas Chavko, Olawale A. Aderemi, Michael A. Dubick, Leopoldo C. Cancio, Yansong Li, Bin Liu, and Milomir O. Simovic, “Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation,” PLoS ONE, vol. 13, no. 8, 2018. View at Publisher · View at Google Scholar
  • Vahagn C. Nikolian, Yuzi Tian, Baoling Liu, Umar F. Bhatti, Isabel S. Dennahy, Basil M. Baccouche, Aaron M. Williams, Jing Zhou, Qiufang Deng, Yongqing Li, Gregory L. Hays, Julia L. Hays, Hasan B. Alam, Kiril Chtraklin, Panpan Chang, Nathan J. Graham, Shalini Roy, and Mohammed Harajli, “Complete and partial aortic occlusion for the treatment of hemorrhagic shock in swine,” Journal of Visualized Experiments, vol. 2018, no. 138, 2018. View at Publisher · View at Google Scholar
  • Vahagn C. Nikolian, Simone E. Dekker, Ted Bambakidis, Gerald A. Higgins, Isabel S. Dennahy, Patrick E. Georgoff, Aaron M. Williams, Anuska V. Andjelkovic, and Hasan B. Alam, “Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma,” Critical Care Medicine, vol. 46, no. 1, pp. e59–e66, 2018. View at Publisher · View at Google Scholar
  • Nikolaos Evangelatos, Pia Bauer, Matthias Reumann, Kapaettu Satyamoorthy, Hans Lehrach, and Angela Brand, “Metabolomics in Sepsis and Its Impact on Public Health,” Public Health Genomics, vol. 20, no. 5, pp. 274–285, 2018. View at Publisher · View at Google Scholar
  • Kazuyasu Fujii, Norihiro Suzuki, Nozomi Jimura, Masashi Idogawa, Tadashi Kondo, Keiji Iwatsuki, and Takuro Kanekura, “HSP72 functionally inhibits the anti-neoplastic effects of HDAC inhibitors,” Journal of Dermatological Science, 2018. View at Publisher · View at Google Scholar
  • Qing Ma, Zhiquan Zhang, Jae-Kwang Shim, Talaignair N. Venkatraman, Christopher D. Lascola, Quintin J. Quinones, Joseph P. Mathew, Niccolò Terrando, and Mihai V. Podgoreanu, “Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation,” Frontiers in Neuroscience, vol. 13, 2019. View at Publisher · View at Google Scholar
  • Yu Ran Lee, Hee Kyoung Joo, Eun Ok Lee, Hyun Sil Cho, Sunga Choi, Cuk-Seong Kim, and Byeong Hwa Jeon, “ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1,” International Journal of Molecular Sciences, vol. 20, no. 13, pp. 3178, 2019. View at Publisher · View at Google Scholar
  • Thomas Marandu, Michael Dombek, and Charles H. Cook, “Impact of cytomegalovirus load on host response to sepsis,” Medical Microbiology and Immunology, 2019. View at Publisher · View at Google Scholar
  • Vahagn C. Nikolian, Isabel S. Dennahy, Aaron M. Williams, Umar F. Bhatti, Hassan Eidy, Kiril Chtraklin, Yongqing Li, Hasan B. Alam, Michael Weykamp, and Mohamed H. Ghandour, “Isoform 6-selective histone deacetylase inhibition reduces lesion size and brain swelling following traumatic brain injury and hemorrhagic shock,” Journal of Trauma and Acute Care Surgery, vol. 86, no. 2, pp. 232–239, 2019. View at Publisher · View at Google Scholar