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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 835968, 6 pages
http://dx.doi.org/10.1155/2011/835968
Review Article

Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells

Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA

Received 16 July 2010; Revised 18 May 2011; Accepted 31 May 2011

Academic Editor: Patrick Matthias

Copyright © 2011 Guoqiang Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Stem cells have provided great hope for the treatment of a variety of human diseases. However, the molecular mechanisms underlying stem cell pluripotency, self-renewal, and differentiation remain to be unveiled. Epigenetic regulators, including histone deacetylases (HDACs), have been shown to coordinate with cell-intrinsic transcription factors and various signaling pathways to regulate stem cell pluripotency, self-renewal, and fate determination. This paper focuses on the role of HDACs in the proliferation and neuronal differentiation of neural stem cells and the application of HDAC inhibitors in reprogramming somatic cells to induced pluripotent stem cells (iPSCs). It promises to be an active area of future research.