Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 835968, 6 pages
http://dx.doi.org/10.1155/2011/835968
Review Article

Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells

Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA

Received 16 July 2010; Revised 18 May 2011; Accepted 31 May 2011

Academic Editor: Patrick Matthias

Copyright © 2011 Guoqiang Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Wichterle and S. Przedborski, “What can pluripotent stem cells teach us about neurodegenerative diseases,” Nature Neuroscience, vol. 13, no. 7, pp. 800–804, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. L. C. Cheng, M. Tavazoie, and F. Doetsch, “Stem cells: from epigeneticsto microRNAs,” Neuron, vol. 46, no. 3, pp. 363–367, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. R. D. Hawkins, G. C. Hon, L. K. Lee et al., “Distinct epigenomic landscapes of pluripotent and lineage-committed human cells,” Cell Stem Cell, vol. 6, no. 5, pp. 479–491, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. P. Koche, Z. D. Smith, M. Adli et al., “Reprogramming factor expression initiates widespread targeted chromatin remodeling,” Cell Stem Cell, vol. 8, no. 1, pp. 96–105, 2011. View at Publisher · View at Google Scholar
  5. Y. Shi, X. Zhao, J. Hsieh et al., “MicroRNA regulation of neural stem cells and neurogenesis,” Journal of Neuroscience, vol. 30, no. 45, pp. 14931–14936, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. V. E. MacDonald and L. A. J. Howe, “Histone acetylation: where to go and how to get there,” Epigenetics, vol. 4, no. 3, pp. 139–143, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. L. Clayton, C. A. Hazzalin, and L. C. Mahadevan, “Enhanced histone acetylation and transcription: a dynamic perspective,” Molecular Cell, vol. 23, no. 3, pp. 289–296, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Haberland, R. L. Montgomery, and E. N. Olson, “The many roles of histone deacetylases in development and physiology: Implications for disease and therapy,” Nature Reviews Genetics, vol. 10, no. 1, pp. 32–42, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. J. Ruthenburg, H. Li, D. J. Patel, and C. D. Allis, “Multivalent engagement of chromatin modifications by linked binding modules,” Nature Reviews Molecular Cell Biology, vol. 8, no. 12, pp. 983–994, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Kouzarides, “Acetylation: a regulatory modification to rival phosphorylation,” EMBO Journal, vol. 19, no. 6, pp. 1176–1179, 2000. View at Google Scholar · View at Scopus
  11. A. Alvarez-Buylla and S. Temple, “Stem cells in the developing and adult nervous system,” Journal of Neurobiology, vol. 36, no. 2, pp. 105–110, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. F. H. Gage, G. Kempermann, T. D. Palmer, D. A. Peterson, and J. Ray, “Multipotent progenitor cells in the adult dentate gyrus,” Journal of Neurobiology, vol. 36, no. 2, pp. 249–266, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. R. McKay, “Stem cells in the central nervous system,” Science, vol. 276, no. 5309, pp. 66–71, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Weiss and D. van der Kooy, “CNS stem cells: Where's the biology (a.k.a. beef)?” Journal of Neurobiology, vol. 36, no. 2, pp. 307–314, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Shi, G. Sun, C. Zhao, and R. Stewart, “Neural stem cell self-renewal,” Critical Reviews in Oncology/Hematology, vol. 65, no. 1, pp. 43–53, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. I. H. Park, R. Zhao, J. A. West et al., “Reprogramming of human somatic cells to pluripotency with defined factors,” Nature, vol. 451, no. 7175, pp. 141–146, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Takahashi, K. Tanabe, M. Ohnuki et al., “Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, vol. 131, no. 5, pp. 861–872, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Yu, M. A. Vodyanik, K. Smuga-Otto et al., “Induced pluripotent stem cell lines derived from human somatic cells,” Science, vol. 318, no. 5858, pp. 1917–1920, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Shi, “Induced pluripotent stem cells, new tools for drug discovery and new hope for stem cell therapies,” Current Molecular Pharmacology, vol. 2, no. 1, pp. 15–18, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Temple, “Stem cell plasticity—building the brain of our dreams,” Nature Reviews Neuroscience, vol. 2, no. 7, pp. 513–520, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Sun, R. T. Yu, R. M. Evans, and Y. Shi, “Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 39, pp. 15282–15287, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. J. L. MacDonald and A. J. Roskams, “Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development,” Developmental Dynamics, vol. 237, no. 8, pp. 2256–2267, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Liu, Q. Hu, A. Kaufman, A. J. D'Ercole, and P. Ye, “Developmental expression of histone deacetylase 11 in the murine brain,” Journal of Neuroscience Research, vol. 86, no. 3, pp. 537–543, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Shi, C. D. Lie, P. Taupin et al., “Expression and function of orphan nuclear receptor TLX in adult neural stem cells,” Nature, vol. 427, no. 6969, pp. 78–83, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Zupkovitz, R. Grausenburger, R. Brunmeir et al., “The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation,” Molecular and Cellular Biology, vol. 30, no. 5, pp. 1171–1181, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Ocker and R. Schneider-Stock, “Histone deacetylase inhibitors: signalling towards p21cip1/waf1,” International Journal of Biochemistry and Cell Biology, vol. 39, no. 7-8, pp. 1367–1374, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. A. L. Gartel and A. L. Tyner, “Transcriptional regulation of the p21((WAF1/CIP1)) gene,” Experimental Cell Research, vol. 246, no. 2, pp. 280–289, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Nakano, T. Mizuno, Y. Sowa et al., “Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line,” Journal of Biological Chemistry, vol. 272, no. 35, pp. 22199–22206, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Lagger, A. Doetzlhofer, B. Schuettengruber et al., “The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene,” Molecular and Cellular Biology, vol. 23, no. 8, pp. 2669–2679, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. V. Balasubramaniyan, E. Boddeke, R. Bakels et al., “Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells,” Neuroscience, vol. 143, no. 4, pp. 939–951, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Hao, T. Creson, L. Zhang et al., “Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis,” Journal of Neuroscience, vol. 24, no. 29, pp. 6590–6599, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Hsieh, K. Nakashima, T. Kuwabara, E. Mejia, and F. H. Gage, “Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 47, pp. 16659–16664, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. F. A. Siebzehnrubl, R. Buslei, I. Y. Eyupoglu, S. Seufert, E. Hahnen, and I. Blumcke, “Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells,” Experimental Brain Research, vol. 176, no. 4, pp. 672–678, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. I. T. Yu, J. Y. Park, S. H. Kim, J. S. Lee, Y. S. Kim, and H. Son, “Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation,” Neuropharmacology, vol. 56, no. 2, pp. 473–480, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Zupkovitz, J. Tischler, M. Posch et al., “Negative and positive regulation of gene expression by mouse histone deacetylase 1,” Molecular and Cellular Biology, vol. 26, no. 21, pp. 7913–7928, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. R. L. Montgomery, J. Hsieh, A. C. Barbosa, J. A. Richardson, and E. N. Olson, “Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 19, pp. 7876–7881, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Jawerka, D. Colak, L. Dimou et al., “The specific role of histone deacetylase 2 in adult neurogenesis,” Neuron Glia Biology, vol. 6, no. 2, pp. 93–107, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. D. M. Chuang, Y. Leng, Z. Marinova, H. J. Kim, and C. T. Chiu, “Multiple roles of HDAC inhibition in neurodegenerative conditions,” Trends in Neurosciences, vol. 32, no. 11, pp. 591–601, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. C. L. Bowden, A. M. Brugger, A. C. Swann et al., “Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study,” Journal of the American Medical Association, vol. 271, no. 12, pp. 918–924, 1994. View at Publisher · View at Google Scholar
  40. J. A. Thomson, J. Itskovitz-Eldor, S. S. Shapiro et al., “Embryonic stem cell lines derived from human blastocysts,” Science, vol. 282, no. 5391, pp. 1145–1147, 1998. View at Google Scholar
  41. N. Maherali, R. Sridharan, W. Xie et al., “Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution,” Cell Stem Cell, vol. 1, no. 1, pp. 55–70, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. K. Okita, T. Ichisaka, and S. Yamanaka, “Generation of germline-competent induced pluripotent stem cells,” Nature, vol. 448, no. 7151, pp. 313–317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Takahashi and S. Yamanaka, “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Wernig, A. Meissner, R. Foreman et al., “In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state,” Nature, vol. 448, no. 7151, pp. 318–324, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Hochedlinger and K. Plath, “Epigenetic reprogramming and induced pluripotency,” Development, vol. 136, no. 4, pp. 509–523, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. E. Kiskinis and K. Eggan, “Progress toward the clinical application of patient-specific pluripotent stem cells,” Journal of Clinical Investigation, vol. 120, no. 1, pp. 51–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Huangfu, K. Osafune, R. Maehr et al., “Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2,” Nature Biotechnology, vol. 26, no. 11, pp. 1269–1275, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. D. Huangfu, R. Maehr, W. Guo et al., “Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds,” Nature Biotechnology, vol. 26, no. 7, pp. 795–797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. T. S. Mikkelsen, J. Hanna, X. Zhang et al., “Dissecting direct reprogramming through integrative genomic analysis,” Nature, vol. 454, no. 7200, pp. 49–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. Shi, J. T. Do, C. Desponts, H. S. Hahm, H. R. Schöler, and S. Ding, “A combined chemical and genetic approach for the generation of induced pluripotent stem cells,” Cell Stem Cell, vol. 2, no. 6, pp. 525–528, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Kishigami, E. Mizutani, H. Ohta et al., “Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer,” Biochemical and Biophysical Research Communications, vol. 340, no. 1, pp. 183–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Rybouchkin, Y. Kato, and Y. Tsunoda, “Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer,” Biology of Reproduction, vol. 74, no. 6, pp. 1083–1089, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. J. L. MacDonald and A. J. Roskams, “Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation,” Progress in Neurobiology, vol. 88, no. 3, pp. 170–183, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. A. Villar-Garea and M. Esteller, “Histone deacetylase inhibitors: understanding a new wave of anticancer agents,” International Journal of Cancer, vol. 112, no. 2, pp. 171–178, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Warren, P. D. Manos, T. Ahfeldt et al., “Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA,” Cell Stem Cell, vol. 7, no. 5, pp. 618–630, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. F. Anokye-Danso, C. M. Trivedi, D. Juhr et al., “Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency,” Cell Stem Cell, vol. 8, no. 4, pp. 376–388, 2011. View at Publisher · View at Google Scholar