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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 969618, 8 pages
Review Article

Surgical Approaches to Create Murine Models of Human Wound Healing

Department of Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University, 257 Campus Drive, GK210, Stanford, CA 94305, USA

Received 12 September 2010; Accepted 26 October 2010

Academic Editor: Andrea Vecchione

Copyright © 2011 Victor W. Wong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Wound repair is a complex biologic process which becomes abnormal in numerous disease states. Although in vitro models have been important in identifying critical repair pathways in specific cell populations, in vivo models are necessary to obtain a more comprehensive and pertinent understanding of human wound healing. The laboratory mouse has long been the most common animal research tool and numerous transgenic strains and models have been developed to help researchers study the molecular pathways involved in wound repair and regeneration. This paper aims to highlight common surgical mouse models of cutaneous disease and to provide investigators with a better understanding of the benefits and limitations of these models for translational applications.