BioMed Research International

Animal Models of Human Pathology


Publishing date
15 Mar 2011
Status
Published
Submission deadline
15 Sep 2010

Lead Editor

1Institute of Experimental Endocrinology and Oncology, National Council Research, Naples, Italy

2NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases, Santiago University Clinical Hospital, Santiago de Compostela, Spain

3Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Columbus, OH, USA


Animal Models of Human Pathology

Description

Based on the genetic alterations found in humans, multiple models of human pathologies have been generated in genetically engineered or drug-induced animals. These experimental models are valuable tools for understanding physiopathology of the disease and discovering novel therapeutic targets and drugs. In fact, one avenue holding tremendous potential to find therapies against human diseases is the use of intact living systems, where complex biological processes can be examined.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in developing animal models, ranging from invertebrates to large animals, to be used in preclinical applications, improving therapy in various fields of medicine (oncology, cardiovascular, immunology, endocrinology, brain pathologies, etc.). We are particularly interested in manuscripts that report naturally occurring, induced or engineered animal models of human diseases and their preclinical applications. Reviews that summarize all the animal models for a particular pathology, their involvement in preclinical trials, and their future on treatment practice are also particularly welcome. Potential topics include, but are not limited to:

  • Modelling retinoblastoma in rodents
  • The use of animal models in the study of obesity
  • The value of animal models for drug development in autoimmune diseases
  • The genetics of cardiovascular disease: new insights from animal models
  • Understanding pathogenesis and therapy of ataxia telangiectasia (AT) via animal models
  • Experimental animal models of rheumatoid arthritis, lupus erythematosus, and osteoarthritis
  • Small model organisms for neurodegenerative diseases
  • Large animal models of heart failure
  • The pig: a representative animal model for humans
  • Modeling human disease using the nematode Caenorhabditis elegans
  • Drosophila models of human diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 764618
  • - Editorial

Animal Models of Human Pathology

Monica Fedele | Oreste Gualillo | Andrea Vecchione
  • Special Issue
  • - Volume 2011
  • - Article ID 360457
  • - Research Article

Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis

Dong-Hyun Kim | Eun-ju Jeon | ... | Sang Won Yeo
  • Special Issue
  • - Volume 2011
  • - Article ID 407031
  • - Review Article

Dysfunction of Lacrimal and Salivary Glands in Sjögren's Syndrome: Nonimmunologic Injury in Preinflammatory Phase and Mouse Model

Toshiharu Hayashi
  • Special Issue
  • - Volume 2011
  • - Article ID 951043
  • - Review Article

Vanadium Inhalation in a Mouse Model for the Understanding of Air-Suspended Particle Systemic Repercussion

T. I. Fortoul | V. Rodriguez-Lara | ... | A. Muñiz-Rivera-Cambas
  • Special Issue
  • - Volume 2011
  • - Article ID 141039
  • - Review Article

Genetically Modified Mouse Models Used for Studying the Role of the AT2 Receptor in Cardiac Hypertrophy and Heart Failure

Maria D. Avila | James P. Morgan | Xinhua Yan
  • Special Issue
  • - Volume 2011
  • - Article ID 373781
  • - Research Article

The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity

Amanda Foskett | Mawadda Alnaeeli | ... | Constance T. Noguchi
  • Special Issue
  • - Volume 2011
  • - Article ID 406473
  • - Review Article

Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases

Tsutomu Kobayashi | Takashi Ito | Masashi Shiomi
  • Special Issue
  • - Volume 2011
  • - Article ID 394241
  • - Review Article

Animal Models of Middle Ear Cholesteatoma

Tomomi Yamamoto-Fukuda | Haruo Takahashi | Takehiko Koji
  • Special Issue
  • - Volume 2011
  • - Article ID 903097
  • - Review Article

Methotrexate Toxicity in Growing Long Bones of Young Rats: A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children

Chiaming Fan | Kristen R. Georgiou | ... | Cory J. Xian
  • Special Issue
  • - Volume 2011
  • - Article ID 527201
  • - Review Article

A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration

Simon C. Spanswick | Hugo Lehmann | Robert J. Sutherland
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision81 days
Acceptance to publication53 days
CiteScore2.410
Impact Factor2.197
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