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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 125384, 11 pages
http://dx.doi.org/10.1155/2012/125384
Review Article

Animal Model of Dermatophytosis

1R&D Laboratories, POLA Pharma Inc, 560 Kashio-cho, Totsuka-ku, Yokohama 244-0812, Japan
2Department of Surgical Pathology, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo 143-8541, Japan
3Department of Dermatology, Peking University First Hospital, Beijing 100034, China

Received 9 December 2011; Revised 8 February 2012; Accepted 13 February 2012

Academic Editor: Monica Fedele

Copyright © 2012 Tsuyoshi Shimamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host’s normal immune function. Many scientists have attempted to establish an experimental animal model to elucidate the pathogenesis of human dermatophytosis and evaluate drug efficacy. However, current animal models have several issues. In the present paper, we surveyed reports about the methodology of the dermatophytosis animal model for tinea corporis, tinea pedis, and tinea unguium and discussed future prospects.