Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 132876, 9 pages
http://dx.doi.org/10.1155/2012/132876
Research Article

Neurodevelopment of Amazonian Infants: Antenatal and Postnatal Exposure to Methyl- and Ethylmercury

1Department of Nutrition, University of Brasília, 70919-970 Brasília, DF, Brazil
2Federal University of Rio de Janeiro, Campus Macaé, 27971-550 Rio de Janeiro, RJ, Brazil
3Departament of Statistics, Federal University of São Carlos, 13566-590 São Carlos, SP, Brazil

Received 5 December 2011; Accepted 4 February 2012

Academic Editor: João B.T. Rocha

Copyright © 2012 José G. Dórea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [43 citations]

The following is the list of published articles that have cited the current article.

  • Jose G. Dorea, “Policy Statements on Breastfeeding and Human Milk: Additional Comments,” Pediatrics, vol. 130, no. 2, pp. E462–E464, 2012. View at Publisher · View at Google Scholar
  • Jose G. Dorea, “Neurotoxic Metal Coexposures and Neurodevelopment,” Environmental Health Perspectives, vol. 120, no. 6, pp. A226–A226, 2012. View at Publisher · View at Google Scholar
  • Jose G. Dorca, “Re: Prenatal Exposure to Mercury and Infant Neurodevelopment in a Multicenter Cohort in Spain: Study of Potential Modifiers,” American Journal Of Epidemiology, vol. 176, no. 12, pp. 1194–1195, 2012. View at Publisher · View at Google Scholar
  • José G. Dórea, “"Impact of mercury on human health and the environment" and special consideration to vulnerability in early life,” Archivos Argentinos de Pediatria, vol. 110, no. 5, pp. 372–373, 2012. View at Publisher · View at Google Scholar
  • Joség. Dórea, “Breast-feeding and responses to infant vaccines: Constitutional and environmental factors,” American Journal of Perinatology, vol. 29, no. 10, pp. 759–775, 2012. View at Publisher · View at Google Scholar
  • Janet K. Kern, Boyd E. Haley, David A. Geier, Lisa K. Sykes, Paul G. King, and Mark R. Geier, “Thimerosal Exposure and the Role of Sulfation Chemistry and Thiol Availability in Autism,” International Journal of Environmental Research and Public Health, vol. 10, no. 8, pp. 3771–3800, 2013. View at Publisher · View at Google Scholar
  • Martina Rudgalvyte, Natalia VanDuyn, Vuokko Aarnio, Liisa Heikkinen, Juhani Peltonen, Merja Lakso, Richard Nass, and Garry Wong, “Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific miRNAs in Caenorhabditis elegans,” Toxicology Letters, 2013. View at Publisher · View at Google Scholar
  • José G. Dórea, Marcelo Farina, and João B. T. Rocha, “Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury,” Journal of Applied Toxicology, 2013. View at Publisher · View at Google Scholar
  • Wanderley R. Bastos, Solange M. Vieira, Ronaldo de Almeida, Igor B. B. Holanda, Marilia H. Mussy, Roberta C. F. Galvao, Pedro T. B. Crispim, and Jose G. Dorea, “Total and methyl-mercury in hair and milk of mothers living in the city of Porto Velho and in villages along the Rio Madeira, Amazon, Brazil,” International Journal of Hygiene and Environmental Health, vol. 216, no. 6, pp. 682–689, 2013. View at Publisher · View at Google Scholar
  • José G. Dórea, “Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants,” Current Medicinal Chemistry, vol. 20, no. 32, pp. 4060–4069, 2013. View at Publisher · View at Google Scholar
  • Mônica P. L. Cunha, José G. Dórea, Rejane C. Marques, and Renata S. Leão, “Vaccine Adverse Events Reported during the First Ten Years (1998–2008) after Introduction in the State of Rondonia, Brazil,” BioMed Research International, vol. 2013, pp. 1–6, 2013. View at Publisher · View at Google Scholar
  • Herman Gibb, and Keri Grace O'Leary, “Mercury Exposure and Health Impacts among Individuals in the Artisanal and Small-Scale Gold Mining Community: A Comprehensive Review,” Environmental Health Perspectives, vol. 122, no. 7, pp. 667–672, 2014. View at Publisher · View at Google Scholar
  • Rejane C. Marques, Jose V. E. Bernardi, Jose G. Dorea, Maria de Fatima R. Moreira, and Olaf Malm, “Perinatal multiple exposure to neurotoxic (lead, methylmercury, ethylmercury, and aluminum) substances and neurodevelopment at six and 24 months of age,” Environmental Pollution, vol. 187, pp. 130–135, 2014. View at Publisher · View at Google Scholar
  • José G. Dórea, Rejane C. Marques, and Luciana Abreu, “Milestone Achievement and Neurodevelopment of Rural Amazonian Toddlers (12 to 24 Months) with Different Methylmercury and Ethylmercury Exposure,” Journal of Toxicology and Environmental Health, Part A, vol. 77, no. 1-3, pp. 1–13, 2014. View at Publisher · View at Google Scholar
  • Rejane C. Marques, José V. E. Bernardi, Luciana Abreu, and José G. Dórea, “Neurodevelopment Outcomes in Children Exposed to Organic Mercury from Multiple Sources in a Tin-Ore Mine Environment in Brazil,” Archives of Environmental Contamination and Toxicology, 2014. View at Publisher · View at Google Scholar
  • David A. Geier, Brian S. Hooker, Paul G. King, Lisa K. Sykes, Mark R. Geier, and Janet K. Kern, “Thimerosal-containing hepatitis B vaccination and the risk for diagnosed specific delays in development in the United States: A case-control study in the vaccine safety datalink,” North American Journal of Medical Sciences, vol. 6, no. 10, pp. 519–531, 2014. View at Publisher · View at Google Scholar
  • Mary C Sheehan, Thomas A Burke, Ana Navas-Acien, Patrick N Breysse, John McGready, and Mary A Fox, “Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review,” Bulletin of the World Health Organization, vol. 92, no. 4, pp. 254–269F, 2014. View at Publisher · View at Google Scholar
  • Brian Hooker, Janet Kern, David Geier, Boyd Haley, Lisa Sykes, Paul King, and Mark Geier, “Methodological Issues and Evidence of Malfeasance in Research Purporting to Show Thimerosal in Vaccines Is Safe,” BioMed Research International, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • David A. Geier, Paul G. King, Brian S. Hooker, José G. Dórea, Janet K. Kern, Lisa K. Sykes, and Mark R. Geier, “Thimerosal: Clinical, Epidemiologic and Biochemical Studies,” Clinica Chimica Acta, 2015. View at Publisher · View at Google Scholar
  • Jose G. Dorea, “The neurological effects of prenatal and postnatal exposure to mercury need to include ethylmercury,” Chemosphere, vol. 139, pp. 667–668, 2015. View at Publisher · View at Google Scholar
  • José Dórea, “Exposure to Mercury and Aluminum in Early Life: Developmental Vulnerability as a Modifying Factor in Neurologic and Immunologic Effects,” International Journal of Environmental Research and Public Health, vol. 12, no. 2, pp. 1295–1313, 2015. View at Publisher · View at Google Scholar
  • Farida El Baz Mohamed, Eman Ahmed Zaky, Adel Bassuoni El-Sayed, Reham Mohammed Elhossieny, Sally Soliman Zahra, Waleed Salah Eldin, Walaa Yousef Youssef, Rania Abdelmgeed Khaled, and Azza Mohamed Youssef, “Assessment of Hair Aluminum, Lead, and Mercury in a Sample of Autistic Egyptian Children: Environmental Risk Factors of Heavy Metals in Autism,” Behavioural Neurology, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • José G. Dórea, and Rejane C Marques, “Mercury levels and human health in the Amazon Basin,” Annals of Human Biology, pp. 1–11, 2016. View at Publisher · View at Google Scholar
  • J. Souza-Araujo, T. Giarrizzo, M. O. Lima, and M. B. G. Souza, “Mercury and methyl mercury in fishes from Bacajá River (Brazilian Amazon): evidence for bioaccumulation and biomagnification,” Journal of Fish Biology, 2016. View at Publisher · View at Google Scholar
  • Lei Yin, Kevin Yu, Simon Lin, Xiao Song, and Xiaozhong Yu, “Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012,” Ecotoxicology and Environmental Safety, vol. 134, pp. 213–225, 2016. View at Publisher · View at Google Scholar
  • Claudia Simone Baltazar de Oliveira, Luiz Carlos de Lima Silveira, Thiago Matos Cruz, Givago da Silva Souza, Maria da Conceição Nascimento Pinheiro, Edem Oliveira Milhomem Filho, and José Maria Farah Costa Junior, “The intake of fish and the mercury concentration of fishing families at the city of Imperatriz (MA), Brazil,” Revista Brasileira de Epidemiologia, vol. 19, no. 1, pp. 14–25, 2016. View at Publisher · View at Google Scholar
  • Rejane C. Marques, Luciana Abreu, José V.E. Bernardi, and José G. Dórea, “Neurodevelopment of Amazonian children exposed to ethylmercury (from Thimerosal in vaccines) and methylmercury (from fish),” Environmental Research, 2016. View at Publisher · View at Google Scholar
  • Carmen I.R. Froes Asmus, Volney M. Camara, Philip J. Landrigan, and Luz Claudio, “A Systematic Review of Children's Environmental Health in Brazil,” Annals of Global Health, vol. 82, no. 1, pp. 132–148, 2016. View at Publisher · View at Google Scholar
  • G. Morris, B. K. Puri, R. E. Frye, and M. Maes, “The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes,” Molecular Neurobiology, 2017. View at Publisher · View at Google Scholar
  • M. R. Cerbino, José Cavalcante Souza Vieira, C. P. Braga, G. Oliveira, I. F. Padilha, T. M. Silva, L. F. Zara, N. J. Silva, and P. M. Padilha, “Metalloproteomics Approach to Analyze Mercury in Breast Milk and Hair Samples of Lactating Women in Communities of the Amazon Basin, Brazil,” Biological Trace Element Research, 2017. View at Publisher · View at Google Scholar
  • David Kwaku Bansa, Adolf Kofi Awua, Rose Boatin, Theodosia Adom, Edward Christian Brown-Appiah, Kennedy Kwame Amewosina, Akusika Diaba, Dominic Datoghe, and Wilhelmina Okwabi, “Cross-sectional assessment of infants’ exposure to toxic metals through breast milk in a prospective cohort study of mining communities in Ghana,” BMC Public Health, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Vasco Branco, Sam Caito, Marcelo Farina, João Teixeira da Rocha, Michael Aschner, and Cristina Carvalho, “Biomarkers of mercury toxicity: Past, present, and future trends,” Journal of Toxicology and Environmental Health, Part B, pp. 1–36, 2017. View at Publisher · View at Google Scholar
  • José G. Dórea, “Abating Mercury Exposure in Young Children Should Include Thimerosal-Free Vaccines,” Neurochemical Research, 2017. View at Publisher · View at Google Scholar
  • David A. Geier, Janet K. Kern, Kristin G. Homme, and Mark R. Geier, “Abnormal Brain Connectivity Spectrum Disorders Following Thimerosal Administration,” Dose-Response, vol. 15, no. 1, pp. 155932581769084, 2017. View at Publisher · View at Google Scholar
  • José G. Dórea, “Low-dose Thimerosal in pediatric vaccines: Adverse effects in perspective,” Environmental Research, vol. 152, pp. 280–293, 2017. View at Publisher · View at Google Scholar
  • Zahra Namvarpour, Mohammad Nasehi, Abdollah Amini, and Mohammad-Reza Zarrindast, “Protective role of alpha-lipoic acid in impairments of social and stereotyped behaviors induced by early postnatal administration of thimerosal in male rat,” Neurotoxicology and Teratology, vol. 67, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • José G. Dórea, “Low-dose Thimerosal (ethyl-mercury) is still used in infants` vaccines: should we be concerned with this form of exposure?,” Journal of Trace Elements in Medicine and Biology, 2018. View at Publisher · View at Google Scholar
  • David A. Geier, Janet K. Kern, Kristin G. Homme, and Mark R. Geier, “The risk of neurodevelopmental disorders following Thimerosal-containing Hib vaccine in comparison to Thimerosal-free Hib vaccine administered from 1995 to 1999 in the United States,” International Journal of Hygiene and Environmental Health, 2018. View at Publisher · View at Google Scholar
  • Joyce dos Santos Freitas, Eliza Maria da Costa Brito Lacerda, Isabelle Christine Vieira da Silva Martins, Dario Rodrigues, Daniela Maria Oliveira Bonci, Maria Izabel Tentes Cortes, Tereza Cristina Oliveira Corvelo, Dora Fix Ventura, Luiz Carlos de Lima Silveira, Maria da Conceição Nascimento Pinheiro, and Givago da Silva Souza, “Cross-sectional study to assess the association of color vision with mercury hair concentration in children from Brazilian Amazonian riverine communities,” NeuroToxicology, 2018. View at Publisher · View at Google Scholar
  • Gabriela S.A. Sampaio, Karen Renata H.M. Oliveira, Nayara Kauffmann, José Luiz M. do Nascimento, Givago S. Souza, Bruno D. Gomes, Silene Maria A. de Lima, Luiz Carlos L. Silveira, Fernando Allan F. Rocha, and Anderson M. Herculano, “Methylmercury alters the number and topography of NO-synthase positive neurons in embryonic retina: Protective effect of alpha-tocopherol,” Toxicology in Vitro, vol. 53, pp. 89–98, 2018. View at Publisher · View at Google Scholar
  • José G. Dórea, “Multiple low-level exposures: Hg interactions with co-occurring neurotoxic substances in early life,” Biochimica et Biophysica Acta (BBA) - General Subjects, 2018. View at Publisher · View at Google Scholar
  • Cláudia S. Oliveira, Pablo A. Nogara, Daniel M.P. Ardisson-Araújo, Michael Aschner, João B.T. Rocha, and José G. Dórea, “Neurodevelopmental Effects of Mercury,” Linking Environmental Exposure to Neurodevelopmental Disorders, vol. 2, pp. 27–86, 2018. View at Publisher · View at Google Scholar
  • Angelica Ramos, Matheus M. dos Santos, Gabriel T. de Macedo, Guilherme Wildner, Alessandro S. Prestes, Claudio A. Masuda, Cristiane L. Dalla Corte, João Batista Teixeira da Rocha, and Nilda V. Barbosa, “Methyl and Ethylmercury elicit oxidative stress and unbalance the antioxidant system in Saccharomyces cerevisiae,” Chemico-Biological Interactions, pp. 108867, 2019. View at Publisher · View at Google Scholar