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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 961461, 7 pages
Research Article

What Sequences on High-Field MR Best Depict Temporal Resolution of Experimental ICH and Edema Formation in Mice?

1Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
2Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
3Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
4Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
5Division of Endovascular Neurosurgery and Interventional Neuroradiology, Departments of Radiology and Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

Received 3 January 2012; Accepted 27 February 2012

Academic Editor: Oreste Gualillo

Copyright © 2012 Mingchang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Purpose. Pilot study to examine the use of T1-, T2-, and T2*-weighted images for evaluating hematoma size and extent of edema in mouse brain at high field. Methods. Following collagenase-induced intracerebral hemorrhage, nine mice were imaged at 4.7 T using T1-, T2-, and T2*-weighted images for hematoma and edema quantitation on days 1, 3, 10, and 21 after surgery. Values were compared with morphometric analysis of cryosections at the time of final MR imaging. Results. For hematoma quantitation, the Spearman correlation coefficient ( 𝑟 ) between T1 signal change and histology was 0.70 ( 𝑃 < 0 . 0 4 ) compared with 𝑟 = 0 . 6 1 ( 𝑃 < 0 . 0 9 ) for T2*. The extent of perihematomal edema formation on cryosections was well reflected on T2 with 𝑟 = 0 . 7 3 ( 𝑃 < 0 . 0 3 ). Conclusions. Within the limits of our pilot study, MR imaging on 4.7 T appears to approximate the temporal changes in hematoma and edema sizes in murine ICH well, thus laying the groundwork for longitudinal studies on hematoma resorption and edema formation.