IL-6 Production by Dendritic Cells Is Dispensable for CD8⁺ Memory T-Cell Generation

Figure 4

Generation of functional OVA-specific CD8⁺ effector T cells following immunization with IL-6-deficient DCs.Mice were immunized as in Figure 3 and effector molecules production was analyzed following a short in vitro stimulation with the OVA peptide. The overlays show production of the different effector molecules by OVA-specific Te cells (CD8⁺CD45.2⁺) compared to endogenous T cells (CD8⁺CD45.2⁻) at day 4 post-immunization with WT (left) or IL-6 KO (right) DCs. The MFI of effector molecule expression by OVA-specific CD8⁺ effectors (upper bold number) and endogenous CD8⁺ T cells (lower number) are indicated on each overlay.

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