Reconstruction and Analysis of Human Kidney-Specific Metabolic Network Based on Omics Data

Figure 5

The flux variability analysis of DEG in DKD. The mutation effects of six DEG on the metabolic network flexibility are shown. It indicates that the flux spans of the metabolic reactions evidently fluctuate for the six genes, especially LPL (Entrez gene ID: 4023). The 𝑦 axis represents reaction count, and the 𝑥 axis represents the flux span ratio of knockout strains to wild-type strains. The genes are represented by Entrez gene ID as shown in Table 2.