BioMed Research International / 2013 / Article / Tab 2

Research Article

Reconstruction and Analysis of Human Kidney-Specific Metabolic Network Based on Omics Data

Table 2

Selected DEG in DKD for FVA analysis.

Gene symbolEntrez gene IDFC (glomeruli)FC (tubuli)ReactionGene name

LPL4023−9.18501−4.38411LPS; LPS2Lipoprotein lipase

GCNT392452.127391.847147CORE4GTgGlucosaminyl (N-acetyl) transferase 3

NNMT48374.3536187.890573NNMTNicotinamide N-methyltransferase

RRM262412.5266493.055954RNDR1;
RNDR2;
RNDR3;
RNDR4
Ribonucleotidereductase M2 polypeptide

B3GNT110678−2.28274−1.53357B3GNT11gUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1

ASNS440−1.537752.724576DEDOLP1_U;
EX_asn_L(e);
FT
Asparagine synthetase

Note: These DEG were selected from a previous study [4], and their flux spans of metabolic reactions were detected to fluctuate markedly (Figure 5). It suggests the essential role of these genes in DKD process. Knocking out of these genes may cause metabolism alterations and affect the emergence of DKD. The first column is the gene symbol of DEG; the second column is the Entrez gene ID; the third and fourth columns are the fold change value for glomeruli and tubuli cell, respectively; the fifth column shows the representative affected reactions, and the sixth column is gene name.

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