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BioMed Research International
Volume 2013, Article ID 297971, 8 pages
http://dx.doi.org/10.1155/2013/297971
Research Article

Efficacy and Safety of Hepatectomy Performed with Intermittent Portal Triad Clamping with Low Central Venous Pressure

1Department of Surgery, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey
2Department of Nursing, School of Health Sciences, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey
3Department of Biochemistry, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey
4Department of Anesthesiology, School of Medicine, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon, Turkey
5Department of Biostatistics, School of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey

Received 7 October 2013; Accepted 14 November 2013

Academic Editor: Engin Erturk

Copyright © 2013 Serdar Topaloglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. This retrospective study was designed to investigate the efficacy and safety of intermittent portal triad clamping (PTC) with low central venous pressure (CVP) in liver resections. Methods. Between January 2007 and August 2013, 115 patients underwent liver resection with intermittent PTC. The patients’ data were retrospectively analyzed. Results. There were 58 males and 57 females with a mean age of 55 years (±13.7). Cirrhosis was found in 23 patients. Resections were performed for malignant disease in 62.6% ( ) and for benign disease in 37.4% ( ). Major hepatectomy was performed in 26 patients (22.4%). Mean liver ischemia period was 27.1 min (±13.9). The mortality rate was 1.7% and the morbidity rate was 22.6%. Cumulative clamping time ( , ) and operation time ( , ) were significantly correlated with AST alterations (D-AST). Cumulative clamping time ( , ) was significantly correlated with D-ALT. Operation time ( , ) was significantly correlated with D-LDH. Conclusions. Intermittent PTC under low CVP was performed with low morbidity and mortality. Intermittent PTC can be safely applied up to 60 minutes in both normal and impaired livers.