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BioMed Research International
Volume 2013, Article ID 310427, 6 pages
http://dx.doi.org/10.1155/2013/310427
Review Article

Clinical Significance of AFP and PIVKA-II Responses for Monitoring Treatment Outcomes and Predicting Prognosis in Patients with Hepatocellular Carcinoma

Hana Park1,2 and Jun Yong Park3,4,5

1Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si, Republic of Korea
2Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam-si, Republic of Korea
3Department of Internal Medicine, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul, Republic of Korea
4Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea
5Yonsei Liver Cancer Special Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea

Received 21 November 2013; Accepted 9 December 2013

Academic Editor: Mohammad Ahmad al-Shatouri

Copyright © 2013 Hana Park and Jun Yong Park. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Recently, the utility of tumor markers in the hepatocellular carcinoma (HCC) field has received a good deal of attention. Here, we review and summarize the results of studies on the roles played by the α-fetoprotein (AFP) and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) responses in terms of the monitoring of outcomes and prediction of prognosis after various HCC treatments. Methods. Studies lodged in PUBMED and that satisfied our inclusion criteria were reviewed. Results. We reviewed 12 studies measuring both AFP and PIVKA-II responses in HCC patients treated in various ways. The results are presented by treatment modality. Conclusion. Measurement of AFP and PIVKA II marker levels before and after HCC treatment is clinically useful in monitoring of treatment outcomes and prognosis and in predicting recurrence and survival.