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BioMed Research International
Volume 2013, Article ID 560141, 18 pages
http://dx.doi.org/10.1155/2013/560141
Research Article

Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland

Received 2 April 2013; Revised 1 July 2013; Accepted 15 July 2013

Academic Editor: Edineia Lemos de Andrade

Copyright © 2013 Emer P. Reeves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Michael Waisberg, Alvaro Molina-Cruz, Daniel La M. Mizurini, Nidhi Gera, Beatriz C. Sousa, Dongying Ma, Ana C. Leal, Taina Gomes, Michalis Kotsyfakis, Jose M. C. Ribeiro, Jan Lukszo, Karine Reiter, Stephen F. Porcella, Carlo J. Oliveira, Robson Q. Monteiro, Carolina Barillas-Mury, Susan K. Pierce, and Ivo M. B. Francischetti, “Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis,” Plos Pathogens, vol. 10, no. 9, 2014. View at Publisher · View at Google Scholar
  • Oliver J. McElvaney, Niamh O’Reilly, Michelle White, Noreen Lacey, Kerstin Pohl, Tanja Gerlza, David A. Bergin, Hilary Kerr, Cormac McCarthy, M. Emmet O’Brien, Tiziana Adage, Andreas J. Kungl, Emer P. Reeves, and Noel G. McElvaney, “The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis,” Molecular Immunology, 2014. View at Publisher · View at Google Scholar
  • Killian Hurley, Noreen Lacey, Ciara A. O'Dwyer, David A. Bergin, Oliver J. McElvaney, M. Emmet O'Brien, Oisin F. McElvaney, Emer P. Reeves, and Noel G. McElvaney, “Alpha-1 Antitrypsin Augmentation Therapy Corrects Accelerated Neutrophil Apoptosis in Deficient Individuals,” Journal of Immunology, vol. 193, no. 8, pp. 3978–3991, 2014. View at Publisher · View at Google Scholar
  • Ciara A. O'Dwyer, M. Emmet O'Brien, Mark R. Wormald, Michelle M. White, Nessa Banville, Killian Hurley, Cormac McCarthy, Noel G. McElvaney, and Emer P. Reeves, “The BLT1 inhibitory function of α-1 antitrypsin augmentation therapy disrupts leukotriene B4 neutrophil signaling,” Journal of Immunology, vol. 195, no. 8, pp. 3628–3641, 2015. View at Publisher · View at Google Scholar
  • Cheng-Di Wang, Nan Chen, Lin Huang, Jia-Rong Wang, Zhi-Yuan Chen, Ya-Mei Jiang, Ya-Zhou He, and Yu-Lin Ji, “ Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis ,” BioMed Research International, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Michael J. Berridge, “The inositol trisphosphate/calcium signaling pathway in health and disease,” Physiological Reviews, vol. 96, no. 4, pp. 1261–1296, 2016. View at Publisher · View at Google Scholar
  • J. P. Vago, L. P. Tavares, M. A. Sugimoto, G. L. N. Lima, I. Galvao, T. R. de Caux, K. M. Lima, A. L. C. Ribeiro, F. S. Carneiro, F. F. C. Nunes, V. Pinho, M. Perretti, M. M. Teixeira, and L. P. Sousa, “Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1,” The Journal of Immunology, vol. 196, no. 4, pp. 1922–1932, 2016. View at Publisher · View at Google Scholar
  • Michelle M. White, Patrick Geraghty, Elaine Hayes, Stephen Cox, William Leitch, Bader Alfawaz, Gillian M. Lavelle, Oliver J. Mcelvaney, Ryan Flannery, Joanne Keenan, Paula Meleady, Michael Henry, Martin Clynes, Cedric Gunaratnam, Noel G. Mcelvaney, and Emer P. Reeves, “Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease,” EBioMedicine, 2017. View at Publisher · View at Google Scholar
  • William Valdar, Paul B. Watkins, William J. Brock, J. Scott Eaddy, Gregory R. Keele, Yuying Xie, Merrie Mosedale, Yunjung Kim, Sharin E. Roth, Tim Wiltshire, and Robert W. Corty, “Candidate risk factors and mechanisms for tolvaptan-induced liver injury are identified using a collaborative cross approach,” Toxicological Sciences, vol. 156, no. 2, pp. 438–454, 2017. View at Publisher · View at Google Scholar
  • Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, and Fang Wang, “Advanced Role of Neutrophils in Common Respiratory Diseases,” Journal of Immunology Research, vol. 2017, pp. 1–21, 2017. View at Publisher · View at Google Scholar