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Linked References

1. M. Qatanani and M. A. Lazar, “Mechanisms of obesity-associated insulin resistance: many choices on the menu,” Genes and Development, vol. 21, no. 12, pp. 1443–1455, 2007. View at Publisher · View at Google Scholar · View at Scopus
2. W. T. Cefalu, “Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition,” ILAR Journal, vol. 47, no. 3, pp. 186–198, 2006. View at Google Scholar · View at Scopus
3. N. V. Giridharan, “Animal models of obesity and their usefulness in molecular approach to obesity,” Indian Journal of Medical Research, vol. 108, pp. 225–242, 1998. View at Google Scholar · View at Scopus
4. R. R. Kalashikam, K. K. Battula, V. Kirlampalli, J. M. Friedman, and G. Nappanveettil, “Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor,” PLoS ONE, vol. 8, no. 10, Article ID e77679, 2013. View at Publisher · View at Google Scholar
5. N. V. Giridharan, P. Sailaja, and N. Harishankar, “A new obese rat model to study obesity and cardiovascular risks,” Proceedings of CMJ Journal, vol. 96, 2010. View at Google Scholar
6. N. Harishankar, P. U. Kumar, B. Sesikeran, and N. Giridharan, “Obesity associated pathophysiological & histological changes in WNIN obese mutant rats,” Indian Journal of Medical Research, vol. 134, no. 9, pp. 330–340, 2011. View at Google Scholar · View at Scopus
7. S. L. Madhira, G. Nappanveethl, V. Kodavalla, and V. Venkatesan, “Comparison of adipocyte-specific gene expression from WNIN/Ob mutant obese rats, lean control, and parental control,” Molecular and Cellular Biochemistry, vol. 357, pp. 217–225, 2011. View at Publisher · View at Google Scholar · View at Scopus
8. S. L. Madhira, S. S. Challa, M. Chalasani et al., “Promise(s) of mesenchymal stem cells as an in vitro model system to depict pre-diabetic/diabetic milieu in WNIN/GR-Ob mutant rats,” PLoS ONE, vol. 7, no. 10, Article ID e48061, 2012. View at Google Scholar
9. G. Kewalramani, P. J. Bilan, and A. Klip, “Muscle insulin resistance: assault by lipids, cytokines and local macrophages,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 13, no. 4, pp. 382–390, 2010. View at Publisher · View at Google Scholar · View at Scopus
10. C. Wang, Y. Guan, and J. Yang, “Cytokines in the progression of pancreatic β-cell dysfunction,” International Journal of Endocrinology, vol. 2010, Article ID 515136, 10 pages, 2010. View at Publisher · View at Google Scholar
11. S. G. Kiran, R. K. Dorisetty, M. R. Umrani et al., “Pyridoxal 5′ phosphate protects islets against streptozotocin-induced beta-cell dysfunction- in vitro and in vivo,” Experimental Biology and Medicine, vol. 236, no. 4, pp. 456–465, 2011. View at Publisher · View at Google Scholar · View at Scopus
12. R. Kikkawa, “Chronic complications in diabetes mellitus,” British Journal of Nutrition, vol. 84, no. 2, pp. S183–S185, 2000. View at Google Scholar · View at Scopus
13. T. Mitsuhashi, K. Hibi, M. Kosuge et al., “Relation between hyperinsulinemia and nonculprit plaque characteristics in nondiabetic patients with acute coronary syndromes,” JACC: Cardiovascular Imaging, vol. 4, no. 4, pp. 392–401, 2011. View at Publisher · View at Google Scholar · View at Scopus
14. V. Venkatesan, M. Chalsani, S. S. Nawaz, R. R. Bhonde, S. S. Challa, and G. Nappanveettil, “Optimization of condition(s) towards establishment of primary islet cell cultures from WNIN/Ob mutant rat,” Cytotechnology, vol. 64, no. 2, pp. 139–144, 2012. View at Publisher · View at Google Scholar · View at Scopus
15. A. Chairmandurai, S. Kanappa, K. Vadrevu, U. Putcha, and V. Venkatesan, “Recombinant human epidermal growth factor alleviates gastric antral ulcer induced by naproxen: a non-steroidal anti inflammatory drug,” Gastroenterology Research, vol. 3, pp. 1918–2813, 2010. View at Google Scholar
16. R. K. Dorisetty, S. G. Kiran, M. R. Umrani, S. Boindala, R. R. Bhonde, and V. Venkatesan, “Immunolocalization of nestin in pancreatic tissue of mice at different ages,” World Journal of Gastroenterology, vol. 14, no. 46, pp. 7112–7116, 2008. View at Publisher · View at Google Scholar · View at Scopus
17. G. Gobe, “Identification of apoptosis in kidney tissue sections,” Methods in Molecular Biology, vol. 466, pp. 175–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
18. D. T. Finegood, M. D. McArthur, D. Kojwang et al., “β-Cell mass dynamics in Zucker diabetic fatty rats: rosiglitazone prevents the rise in net cell death,” Diabetes, vol. 50, no. 5, pp. 1021–1029, 2001. View at Google Scholar · View at Scopus
19. K. Mishima, A. P. Mazar, A. Gown et al., “A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 15, pp. 8484–8489, 2000. View at Publisher · View at Google Scholar · View at Scopus
20. A.-A. Dussault and M. Pouliot, “Rapid and simple comparison of messenger RNA levels using real-time PCR,” Biological Procedures Online, vol. 8, no. 1, pp. 1–10, 2006. View at Publisher · View at Google Scholar · View at Scopus
21. M. M. Amoli, R. Moosavizadeh, and B. Larijani, “Optimizing conditions for rat pancreatic islets isolation,” Cytotechnology, vol. 48, no. 1–3, pp. 75–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
22. Y.-F. Cui, M. Ma, G.-Y. Wang, D.-E. Han, B. Vollmar, and M. D. Menger, “Prevention of core cell damage in isolated islets of Langerhans by low temperature preconditioning,” World Journal of Gastroenterology, vol. 11, no. 4, pp. 545–550, 2005. View at Google Scholar · View at Scopus
23. S. S. Challa, G. S. Kiran, R. R. Bhonde, and V. Venkatesan, “Enhanced neogenic potential of Panc-1 cells supplemented with human umbilical cord blood serum-An alternative to FCS,” Tissue and Cell, vol. 43, no. 4, pp. 266–270, 2011. View at Publisher · View at Google Scholar · View at Scopus
24. H. Xu, G. T. Barnes, Q. Yang et al., “Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1821–1830, 2003. View at Publisher · View at Google Scholar · View at Scopus
25. L. Singotamu and P. M. Chary, “Scanning electron microscope studies on genetically modified (GM) crops–G.M. cotton fiber (Gossypium herbaceum),” Scanning, vol. 27, no. 3, pp. 160–161, 2005. View at Google Scholar · View at Scopus
26. V. Vijayalakshmi and P. D. Gupta, “Role of transglutaminase in keratinization of vaginal epithelial cells in oestrous cycling rats,” Biochemistry and Molecular Biology International, vol. 43, no. 5, pp. 1041–1049, 1997. View at Google Scholar · View at Scopus
27. M. Cnop, N. Welsh, J.-C. Jonas, A. Jörns, S. Lenzen, and D. L. Eizirik, “Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities,” Diabetes, vol. 54, no. 2, pp. S97–S107, 2005. View at Publisher · View at Google Scholar · View at Scopus
28. J. A. Ehses, A. Perren, E. Eppler et al., “Increased number of islet-associated macrophages in type 2 diabetes,” Diabetes, vol. 56, no. 9, pp. 2356–2370, 2007. View at Publisher · View at Google Scholar · View at Scopus
29. C.-H. Hsieh, Y.-J. Hung, C.-Z. Wu et al., “Insulin resistance & secretion in subjects with normal fasting plasma glucose,” Indian Journal of Medical Research, vol. 124, pp. 527–534, 2006. View at Google Scholar · View at Scopus
30. P. Bandaru, H. Rajkumar, and G. Nappanveettil, “Altered or impaired immune response upon vaccination in WNIN/Ob rats,” Vaccine, vol. 29, no. 16, pp. 3038–3042, 2011. View at Publisher · View at Google Scholar · View at Scopus
31. P. Bandaru, H. Rajkumar, and G. Nappanveettil, “The impact of obesity on immune response to infection and vaccine: an insight into plausible mechanisms,” Endocrinology & Metabolic Syndrome, vol. 2, p. 113, 2013. View at Google Scholar
32. C. Sánchez-Pozo, J. Rodriguez-Baño, A. Domínguez-Castellano, M. A. Muniain, R. Goberna, and V. Sánchez-Margalet, “Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV-infected patients,” Clinical and Experimental Immunology, vol. 134, no. 3, pp. 464–469, 2003. View at Publisher · View at Google Scholar · View at Scopus
33. L. Rui, V. Aguirre, J. K. Kim et al., “Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways,” Journal of Clinical Investigation, vol. 107, no. 2, pp. 181–189, 2001. View at Google Scholar · View at Scopus
34. M. Chentouf, G. Dubois, C. Jahannaut et al., “Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets,” PLoS ONE, vol. 6, no. 8, Article ID e22954, 2011. View at Publisher · View at Google Scholar · View at Scopus
35. O. P. Kristiansen and T. Mandrup-Poulsen, “Interleukin-6 and diabetes: the good, the bad, or the indifferent?” Diabetes, vol. 54, no. 2, pp. S114–S124, 2005. View at Publisher · View at Google Scholar · View at Scopus
36. D. C. Nieman, S. L. Nehlsen-Cannarella, D. A. Henson et al., “Immune response to obesity and moderate weight loss,” International Journal of Obesity, vol. 20, no. 4, pp. 353–360, 1996. View at Google Scholar · View at Scopus
37. D. O'Shea, T. J. Cawood, C. O'Farrelly, and L. Lynch, “Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke,” PloS ONE, vol. 5, no. 1, Article ID e8660, 2010. View at Publisher · View at Google Scholar · View at Scopus
38. J.-P. Bastard, M. Maachi, C. Lagathu et al., “Recent advances in the relationship between obesity, inflammation, and insulin resistance,” European Cytokine Network, vol. 17, no. 1, pp. 4–12, 2006. View at Google Scholar · View at Scopus
39. C. Procaccini, E. Jirillo, and G. Matarese, “Leptin as an immunomodulator,” Molecular Aspects of Medicine, vol. 33, no. 1, pp. 35–45, 2012. View at Publisher · View at Google Scholar · View at Scopus
40. P. Bandaru, H. Rajkumar, V. P. Upadrasta, and G. Nappanveettil, “Role of leptin in immune dysfunction in WNIN obese rats,” Endocrinology & Metabolic Syndrome, vol. 2, p. 116, 2013. View at Google Scholar
41. V. de Rosa, C. Procaccini, G. Calì et al., “A key role of leptin in the control of regulatory T cell proliferation,” Immunity, vol. 26, no. 2, pp. 241–255, 2007. View at Publisher · View at Google Scholar · View at Scopus
42. H. K. Vincent and A. G. Taylor, “Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans,” International Journal of Obesity, vol. 30, no. 3, pp. 400–418, 2006. View at Publisher · View at Google Scholar · View at Scopus
43. P. A. Tataranni and E. Ortega, “A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?” Diabetes, vol. 54, no. 4, pp. 917–927, 2005. View at Publisher · View at Google Scholar · View at Scopus
44. K. E. Wellen and G. S. Hotamisligil, “Obesity-induced inflammatory changes in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1785–1788, 2003. View at Publisher · View at Google Scholar · View at Scopus
45. Y. Saisho, A. E. Butler, E. Manesso, D. Elashoff, R. A. Rizza, and P. C. Butler, “β-cell mass and turnover in humans: effects of obesity and aging,” Diabetes Care, vol. 36, pp. 111–117, 2013. View at Publisher · View at Google Scholar
46. D. A. Nugent, D. M. Smith, and H. B. Jones, “A review of islet of Langerhans degeneration in rodent models of type 2 diabetes,” Toxicologic Pathology, vol. 36, no. 4, pp. 529–551, 2008. View at Publisher · View at Google Scholar · View at Scopus
47. H. Kaneto, T.-A. Matsuoka, S. Kawashima et al., “Role of MafA in pancreatic β-cells,” Advanced Drug Delivery Reviews, vol. 61, no. 7-8, pp. 489–496, 2009. View at Publisher · View at Google Scholar · View at Scopus
48. D. Kawamori, Y. Kajimoto, H. Kaneto et al., “Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH2-terminal kinase,” Diabetes, vol. 52, no. 12, pp. 2896–2904, 2003. View at Publisher · View at Google Scholar · View at Scopus
49. K. L. Lipson, S. G. Fonseca, S. Ishigaki et al., “Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1,” Cell Metabolism, vol. 4, no. 3, pp. 245–254, 2006. View at Publisher · View at Google Scholar · View at Scopus
50. R. J. Kaufman, S. H. Back, B. Song, J. Han, and J. Hassler, “The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells,” Diabetes, Obesity and Metabolism, vol. 12, no. 2, pp. 99–107, 2010. View at Publisher · View at Google Scholar · View at Scopus
51. U. Özcan, Q. Cao, E. Yilmaz et al., “Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes,” Science, vol. 306, no. 5695, pp. 457–461, 2004. View at Publisher · View at Google Scholar · View at Scopus
52. S. Thanumalayan, M. Laxmi Narasu, and V. Venkatesan, “Down regulation of suppressor of potassium transport defect 3 (SKD3) in testis of nonobese diabetic (NOD) mice,” Indian Journal of Veterinary Pathology, vol. 32, pp. 242–245, 2008. View at Google Scholar
53. D. A. Cunha, P. Hekerman, L. Ladrière et al., “Initiation and execution of lipotoxic ER stress in pancreatic β-cells,” Journal of Cell Science, vol. 121, no. 14, pp. 2308–2318, 2008. View at Publisher · View at Google Scholar · View at Scopus
54. W. Quan, Y.-M. Lim, and M.-S. Lee, “Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells,” Experimental and Molecular Medicine, vol. 44, no. 2, pp. 81–88, 2012. View at Publisher · View at Google Scholar · View at Scopus
55. G. B. Reddy, V. Vasireddy, M. N. A. Mandal et al., “A novel rat model with obesity-associated retinal degeneration,” Investigative Ophthalmology and Visual Science, vol. 50, no. 7, pp. 3456–3463, 2009. View at Publisher · View at Google Scholar · View at Scopus
56. N. Harishankar, P. Ravinder, K. M. Nair, and N. Giridharan, “Infertility in WNIN obese mutant rats-causes?” ISRN Endocrinol, vol. 2011, Article ID 863403, 7 pages, 2011. View at Publisher · View at Google Scholar
57. M. Y. Donath, M. Böni-Schnetzler, H. Ellingsgaard, and J. A. Ehses, “Islet inflammation impairs the pancreatic B-ceII in type 2 diabetes,” Physiology, vol. 24, no. 6, pp. 325–331, 2009. View at Publisher · View at Google Scholar · View at Scopus
58. N.-G. Chen, T. M. Tassava, and D. R. Romsos, “Threshold for glucose-stimulated insulin secretion in pancreatic islets of genetically obese (ob/ob) mice is abnormally low,” Journal of Nutrition, vol. 123, no. 9, pp. 1567–1574, 1993. View at Google Scholar · View at Scopus
59. K. Kaneko, K. Ueki, N. Takahashi et al., “Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms,” Cell Metabolism, vol. 12, no. 6, pp. 619–632, 2010. View at Publisher · View at Google Scholar · View at Scopus
60. Y.-L. Ding, Y.-H. Wang, W. Huang et al., “Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia,” Experimental Biology and Medicine, vol. 235, no. 1, pp. 40–46, 2010. View at Publisher · View at Google Scholar · View at Scopus
61. H.-E. Kim, S.-E. Choi, S.-J. Lee et al., “Tumour necrosis factor-α-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx,” Journal of Endocrinology, vol. 198, no. 3, pp. 549–560, 2008. View at Publisher · View at Google Scholar · View at Scopus
62. J. Seufert, “Leptin Effects on Pancreatic β-Cell Gene Expression and Function,” Diabetes, vol. 53, no. 1, pp. S152–S158, 2004. View at Google Scholar · View at Scopus
63. L. P. Roma, S. M. Pascal, J. Duprez, and J. C. Jonas, “Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration,” Diabetologia, vol. 55, pp. 2226–2237, 2012. View at Publisher · View at Google Scholar
64. R. Alemzadeh and K. M. Tushaus, “Modulation of adipoinsular axis in prediabetic Zucker diabetic fatty rats by diazoxide,” Endocrinology, vol. 145, no. 12, pp. 5476–5484, 2004. View at Publisher · View at Google Scholar · View at Scopus
65. G. Üçkaya, P. Delagrange, A. Chavanieu et al., “Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue,” Journal of Endocrinology, vol. 184, no. 3, pp. 505–513, 2005. View at Publisher · View at Google Scholar · View at Scopus
66. M. Y. Donath, M. Böni-Schnetzler, H. Ellingsgaard, P. A. Halban, and J. A. Ehses, “Cytokine production by islets in health and diabetes: cellular origin, regulation and function,” Trends in Endocrinology and Metabolism, vol. 21, no. 5, pp. 261–267, 2010. View at Publisher · View at Google Scholar · View at Scopus