Research Article
GRIN2B Gene and Associated Brain Cortical White Matter Changes in Bipolar Disorder: A Preliminary Combined Platform Investigation
Table 3
The effects of GRIN2B of rs890G/T on brain white matter regions (mean fractional anisotropy).
| | HC () | BD () | ANOVA (unadjusted) | ANCOVAa (adjusted) | |
GG () |
T carriers () |
GG () |
T carriers () |
Diagnosis effect |
Genotype effect |
Interactions effect |
Diagnosis effect |
Genotype effect |
Interactions effect | | Mean | SD | Mean | SD | Mean | SD | Mean | SD | | | | | | | | | | | | |
| Left occipital lobe | 0.150 | 0.027 | 0.137 | 0.016 | 0.207 | — | 0.131 | 0.012 | 6.99 | .013 | 21.4 | <.001 | 10.8 | .002 | 7.06 | .012 | 16.2 | <.001 | 8.93 | .006 | Right occipital lobe | 0.147 | 0.031 | 0.149 | 0.016 | 0.254 | — | 0.145 | 0.016 | 24.9 | <.001 | 26.4 | <.001 | 28.1 | <.001 | 25.4 | <.001 | 20.7 | <.001 | 24.8 | <.001 | Left parietal lobe | 0.177 | 0.005 | 0.174 | 0.014 | 0.248 | — | 0.172 | 0.018 | 13.7 | .001 | 18.2 | <.001 | 15.8 | <.001 | 13.7 | .001 | 14.2 | .001 | 13.0 | .001 | Right parietal lobe | 0.177 | 0.020 | 0.174 | 0.153 | 0.218 | — | 0.175 | 0.021 | 3.78 | .061 | 4.34 | .045 | 3.41 | .074 | 3.58 | .068 | 2.53 | .122 | 2.68 | .112 | Left temporal lobe | 0.164 | 0.004 | 0.163 | 0.009 | 0.163 | — | 0.161 | 0.008 | 0.09 | .764 | 0.11 | .743 | 0.01 | .934 | 0.08 | .783 | 0.13 | .719 | 0.00 | .956 | Right temporal lobe | 0.157 | 0.005 | 0.160 | 0.012 | 0.156 | — | 0.155 | 0.009 | 0.17 | .685 | 0.05 | .832 | 0.09 | .771 | 0.17 | .686 | 0.02 | .898 | 0.17 | .682 | Left frontal lobe | 0.173 | 0.020 | 0.177 | 0.014 | 0.249 | — | 0.159 | 0.016 | 9.96 | .003 | 21.4 | <.001 | 25.5 | <.001 | 9.62 | .004 | 19.0 | <.001 | 22.4 | <.001 | Right frontal lobe | 0.174 | 0.029 | 0.171 | 0.014 | 0.249 | — | 0.161 | 0.017 | 10.9 | .002 | 21.6 | <.001 | 18.7 | <.001 | 10.8 | .003 | 20.9 | <.001 | 17.4 | <.001 | Left cingulate gyrus | 0.217 | 0.021 | 0.217 | 0.014 | 0.280 | — | 0.208 | 0.012 | 10.9 | .002 | 18.6 | <.001 | 18.6 | <.001 | 12.6 | .001 | 24.2 | <.001 | 20.9 | <.001 | Right cingulate gyrus | 0.200 | 0.017 | 0.196 | 0.017 | 0.250 | — | 0.193 | 0.017 | 5.06 | .032 | 8.82 | .006 | 6.47 | .016 | 6.86 | .014 | 13.6 | .001 | 7.16 | .012 |
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Adjusted for age, gender, education, handedness, and intracranial volume. BD: patients with bipolar disorder; HC: healthy controls.
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