GRIN2B Gene and Associated Brain Cortical White Matter Changes in Bipolar Disorder: A Preliminary Combined Platform Investigation

Table 3

The effects of GRIN2B of rs890G/T on brain white matter regions (mean fractional anisotropy).

	HC (𝑛=22)				BD (𝑛=14)				ANOVA (unadjusted)						ANCOVA^a (adjusted)
	GG; (𝑛=3)		T carriers; (𝑛=19)		GG; (𝑛=1)		T carriers; (𝑛=13)		Diagnosis; effect		Genotype; effect		Interactions; effect		Diagnosis; effect		Genotype; effect		Interactions; effect
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	𝐹	𝑃	𝐹	𝑃	𝐹	𝑃	𝐹	𝑃	𝐹	𝑃	𝐹	𝑃
Left occipital lobe	0.150	0.027	0.137	0.016	0.207	—	0.131	0.012	6.99	.013	21.4	<.001	10.8	.002	7.06	.012	16.2	<.001	8.93	.006
Right occipital lobe	0.147	0.031	0.149	0.016	0.254	—	0.145	0.016	24.9	<.001	26.4	<.001	28.1	<.001	25.4	<.001	20.7	<.001	24.8	<.001
Left parietal lobe	0.177	0.005	0.174	0.014	0.248	—	0.172	0.018	13.7	.001	18.2	<.001	15.8	<.001	13.7	.001	14.2	.001	13.0	.001
Right parietal lobe	0.177	0.020	0.174	0.153	0.218	—	0.175	0.021	3.78	.061	4.34	.045	3.41	.074	3.58	.068	2.53	.122	2.68	.112
Left temporal lobe	0.164	0.004	0.163	0.009	0.163	—	0.161	0.008	0.09	.764	0.11	.743	0.01	.934	0.08	.783	0.13	.719	0.00	.956
Right temporal lobe	0.157	0.005	0.160	0.012	0.156	—	0.155	0.009	0.17	.685	0.05	.832	0.09	.771	0.17	.686	0.02	.898	0.17	.682
Left frontal lobe	0.173	0.020	0.177	0.014	0.249	—	0.159	0.016	9.96	.003	21.4	<.001	25.5	<.001	9.62	.004	19.0	<.001	22.4	<.001
Right frontal lobe	0.174	0.029	0.171	0.014	0.249	—	0.161	0.017	10.9	.002	21.6	<.001	18.7	<.001	10.8	.003	20.9	<.001	17.4	<.001
Left cingulate gyrus	0.217	0.021	0.217	0.014	0.280	—	0.208	0.012	10.9	.002	18.6	<.001	18.6	<.001	12.6	.001	24.2	<.001	20.9	<.001
Right cingulate gyrus	0.200	0.017	0.196	0.017	0.250	—	0.193	0.017	5.06	.032	8.82	.006	6.47	.016	6.86	.014	13.6	.001	7.16	.012

aAdjusted for age, gender, education, handedness, and intracranial volume.
BD: patients with bipolar disorder; HC: healthy controls.