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BioMed Research International
Volume 2013, Article ID 759361, 6 pages
http://dx.doi.org/10.1155/2013/759361
Research Article

The SDF-1α3 A Genetic Variation Is Correlated with Susceptibility of Asthma in Iranian Patients

1Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan 77175-835, Iran
3Physiology, Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan 77175-835, Iran
4Department of Immunology, Rafsanjan University of Medical Sciences, Rafsanjan 77175-835, Iran
5Department of Infectious Diseases, Rafsanjan University of Medical Sciences, Rafsanjan 77175-835, Iran
6Faculty of Nursing, Rafsanjan University of Medical Sciences, Rafsanjan 77175-835, Iran
7Kerman University of Medical Sciences, Kerman, Iran

Received 28 February 2013; Revised 15 July 2013; Accepted 16 July 2013

Academic Editor: Oliver Haworth

Copyright © 2013 Houshang Rafatpanah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aim. Chemokine/receptor axis is a predominant actor of clinical disorders. They are key factors of pathogenesis of almost all clinical situations including asthma. Correspondingly, CXCL12 is involved in the immune responses. Therefore, this study was designed to explore the association between gene polymorphism at position +801 of CXCL12, known as , and susceptibility to asthma in Iranian patients. Material and Methods. In this experimental study, samples were taken from 162 asthma patients and 189 healthy controls on EDTA. DNA was extracted and analyzed for CXCL12 polymorphisms using PCR-RLFP. The demographic information was also collected in parallel with the experimental part of the study by a questionnaire which was designed specifically for this study. Findings. Our results indicated a significant difference ( ) between the A/A, A/G, and G/G genotypes and A and G alleles of polymorphisms at position +801 of CXCL12. We also showed an elevated level of CXCL12 circulating level in Iranian asthma patients. Conclusion. Our findings suggest that (CXCL12) polymorphism plays a role in pathogenesis of asthma. It can also be concluded that circulatory level of CXCL12 presumably can be used as one of the pivotal biological markers in diagnosis of asthma.